TY - JOUR AU - Rahimnejad, Maedeh AU - Boroujeni, Narges Nasrollahi AU - Jahangiri, Sepideh AU - Rabiee, Navid AU - Rabiee, Mohammad AU - Makvandi, Pooyan AU - Akhavan, Omid AU - Varma, Rajender S. PY - 2021/08/18 Y2 - 2024/03/28 TI - Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering JF - Nano-Micro Letters JA - Nano-Micro Lett VL - 13 IS - SE - Articles DO - 10.1007/s40820-021-00697-1 UR - https://nmlett.org/index.php/nml/article/view/948 SP - 182 AB - <p>Efficient strategies to promote microvascularization in vascular tissue engineering, a central priority in regenerative medicine, are still scarce; nano- and micro-sized aggregates and spheres or beads harboring primitive microvascular beds are promising methods in vascular tissue engineering. Capillaries are the smallest type and in numerous blood vessels, which are distributed densely in cardiovascular system. To mimic this microvascular network, specific cell components and proangiogenic factors are required. Herein, advanced biofabrication methods in microvascular engineering, including extrusion-based and droplet-based bioprinting, Kenzan, and biogripper approaches, are deliberated with emphasis on the newest works in prevascular nano- and micro-sized aggregates and microspheres/microbeads.</p><p>Highlights:</p><p>1 The first perspective regarding the application of nano-micro size aggregations on the prevascularizations and biomedicine.<br>2 This perspective provides an in-depth discussion regarding the use of these prevascularized nano-micro size aggregates in biomedicine and regenerative medicine.</p><p>&nbsp;</p> ER -