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Vol. 17 (2025)

All-in-One: A Multifunctional Composite Biomimetic Cryogel for Coagulation Disorder Hemostasis and Infected Diabetic Wound Healing

https://doi.org/10.1007/s40820-024-01603-1
Jiaxin Wang
Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China
Yutong Yang
State Key Laboratory for Mechanical Behavior of Materials, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China
Huiru Xu
State Key Laboratory for Mechanical Behavior of Materials, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China
Shengfei Huang
State Key Laboratory for Mechanical Behavior of Materials, Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Frontier Institute of Science and Technology, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China
Baolin Guo
Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China
Juan Hu
Department of Otorhinolaryngology, Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, People’s Republic of China

Corresponding Author: Juan Hu

hjdoc@163.com

Nano-Micro Letters, Vol. 17 (2025), Article Number: 171

Abstract

Traditional hemostatic materials are difficult to meet the needs of non-compressible bleeding and for coagulopathic patients. In addition, open wounds are susceptible to infection, and then develop into chronic wounds. However, the development of integrated dressings that do not depend on coagulation pathway and improve the microenvironment of chronic wounds remains a challenge. Inspired by the porous structure and composition of the natural extracellular matrix, adipic dihydrazide modified gelatin (GA), dodecylamine-grafted hyaluronic acid (HD), and MnO2 nanozyme (manganese dioxide)@DFO (deferoxamine)@PDA (polydopamine) (MDP) nanoparticles were combined to prepare GA/HD/MDP cryogels through amidation reaction and hydrogen bonding. These cryogels exhibited good fatigue resistance, photothermal antibacterial (about 98% killing ratios of both Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA) after 3 min near-infrared irradiation), reactive oxygen species scavenging, oxygen release, and angiogenesis properties. Furthermore, in the liver defect model of rats with coagulopathy, the cryogel displayed less bleeding and shorter hemostasis time than commercial gelatin sponge. In MRSA-infected diabetic wounds, the cryogel could decrease wound inflammation and oxidative stress, alleviate the hypoxic environment, promote collagen deposition, and induce vascular regeneration, showing a better repair effect compared with the Tegaderm™ film. These results indicated that GA/HD/MDP cryogels have great potential in non-compressible hemorrhage for coagulopathic patients and in healing infected wounds for diabetic patients.


Highlights:
1 An all-in-one cryogel is proposed for hemostasis of coagulopathy bleeding and repair of infected diabetic ulcers.
2 The cryogel possesses rapid liquid-triggered volume expansion capability and physicochemical synergistic hemostatic properties.
3 The cryogel can accelerate the healing of infected diabetic wounds by releasing oxygen and deferoxamine.

Keywords

Gelatin-based cryogel Coagulopathic bleeding Non-compressible hemorrhage Diabetic wound healing
Wang, Jiaxin, Yutong Yang, Huiru Xu, Shengfei Huang, Baolin Guo, and Juan Hu. 2025. “All-in-One: A Multifunctional Composite Biomimetic Cryogel for Coagulation Disorder Hemostasis and Infected Diabetic Wound Healing”. Nano-Micro Letters 17 (March):171. https://doi.org/10.1007/s40820-024-01603-1.
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