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Vol. 2 No. 4 (2010)

Optimised NSAIDs-loaded Biocompatible Nanoparticles

https://doi.org/10.1007/BF03353851
V. Gaëlle Roullin
Institut de Chimie Molé culaire de Reims, CNRS UMR 6229, UFR Pharmacie Reims, 51 rue Cognacq-Jay, 51100, Reims, France
Maïté Callewaert
Institut de Chimie Molé culaire de Reims, CNRS UMR 6229, UFR Pharmacie Reims, 51 rue Cognacq-Jay, 51100, Reims, France
Michaël Molinari
Laboratoire de Microscopies et d’Etudes des Nanostructures, UFR des Sciences, Université de Reims Champagne-Ardenne, 21 rue Clé ment Ader, 51685, Reims Cedex 2, France
Franck Delavoie
Laboratoire de Microscopie Electronique Analytique, INSERM UMRS 926, 21 rue Clé ment Ader, 51685, Reims Cedex 2, France
Aurélie Seconde
Institut de Chimie Molé culaire de Reims, CNRS UMR 6229, UFR Pharmacie Reims, 51 rue Cognacq-Jay, 51100, Reims, France
Marie-Christine Andry
Institut de Chimie Molé culaire de Reims, CNRS UMR 6229, UFR Pharmacie Reims, 51 rue Cognacq-Jay, 51100, Reims, France

Corresponding Author: V. Gaëlle Roullin

gaelle.roullin@univ-reims.fr

Nano-Micro Letters, Vol. 2 No. 4 (2010), Article Number: 247-255

Abstract

In this formulation study, biocompatible non steroidal anti-inflammatory (NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization. A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation requirements. Formulation parameters, such as lactide/glycolide ratio, polymer concentration, solvent/non solvent ratio and non solvent phase, as well as the non ionic tensioactive P188 co-precipitation composition were systematically explored. The optimized formulation (mean size: 145 nm, surface charge: −13 mV) was employed to encapsulate various amounts of NSAIDs in a simple and scalable manner. The drug release was characterized in vitro by a complete release for 48 h. These results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.

Keywords

Drug delivery systems (DDS) Biocompatible Emulsion-solvent diffusion method PLGA Glycofurol Non steroidal anti-inflammatory drugs (NSAIDs)
Roullin, V. Gaëlle, Maïté Callewaert, Michaël Molinari, Franck Delavoie, Aurélie Seconde, and Marie-Christine Andry. 2010. “Optimised NSAIDs-Loaded Biocompatible Nanoparticles”. Nano-Micro Letters 2 (4):247-55. https://doi.org/10.1007/BF03353851.
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References
  1. A. Kumari, S. Kumar Yadav and S. C. Yadav, Colloids Surf. B 75, 1 (2010). doi:10.1016/j.colsurfb.2009.09.001
  2. V. Dahl, J. C. Raede, S. Drosdal, O. Wathne and J. Brynildsrud, Acta Anaesthesiol. Scand. 39, 323 (1995). doi:10.1111/j.1399-6576.1995.tb04070.x
  3. M. Fransen, Control. Clin. Trials 25, 223 (2004). doi:10.1016/j.cct.2003.11.008
  4. C. L. Romano, D. Duci, D. Romano, M. Mazza and E. Meani, The Journal of Arthroplasty 19, 14 (2004). doi:10.1016/S0883-5403(03)00279-1
  5. M. Fransen, C. Anderson, J. Douglas, S. MacMahon, B. Neal, R. Norton, M. Woodward, I. D. Cameron, R. Crawford, S. K. Lo, G. Tregonning and M. Windolf, BMJ. 333, 519 (2006). doi:10.1136/bmj.38925.471146.4F
  6. J. P. Cella, E. A. Salvati and T. P. Sculco, The Journal of Arthroplasty 3, 229 (1988).
  7. C. E. Mora-Huertas, H. Fessi and A. Elaissari, Int. J. Pharm. 385, 113 (2010). doi:10.1016/j.ijpharm.2009.10.018
  8. T. Niwa, H. Takeuchi, T. Hino, N. Kunou and Y. Kawashima, J. Controlled Release 25, 89 (1993) doi:10.1016/0168-3659(93)90097-O
  9. P. J. Weller, “Handbook of Pharmaceutical Excipients 5th edition”, London: Pharmaceutical Press, 2006.
  10. N. Csaba, P. Caamaño, A. Sánchez, F. Dominguez and M. J. Alonso, Biomacromolecules 6, 271 (2005). doi:10.1021/bm049577p
  11. O. Albayrak, O. El-Atwani and S. Altintas, Surf. Coat. Technol. 202, 2482 (2008). doi:10.1016/j.surfcoat.2007.09.031
  12. K. Y Win and S. S. Feng, Biomaterials 26, 2713 (2005). doi:10.1016/j.biomaterials.2004.07.050
  13. H. Gao, Y. N. Wang, Y. G. Fan and J. B. Ma, J. Biomed. Mater. Res. Part A 80, 111 (2007). doi:10.1002/jbm.a.30861
  14. T. Riley, S. Stolnik, C. R. Heald, C. D. Xiong, M. C. Garnett, L. Illum and S. S. Davis, Langmuir 17, 3168 (2001). doi:10.1021/la001226i
  15. G. Mittal, D. K. Sahana, V. Bhardwaj and M. N. V. Ravi Kumar, J. Controlled Release 119, 77 (2007). doi:10.1016/j.jconrel.2007.01.016
  16. D. Quintanar-Guerrero, E. Allemann, H. Fessi and E. Doelker, Int. J. Pharm. 188, 155 (1999). doi:10.1016/S0378-5173(99)00216-1
  17. T. Jung, A. Breitenbach and T. Kissell, J. Controlled Release 67, 157 (2000). doi:10.1016/S0168-659(00)002017
  18. J. Cheng, B. A. Teply, I. Sherifi, J. Sung, G. Luther, F. X. 3Langer and O. C. Farokhzad, Biomaterials 28, 869 (2007). doi:10.1016/j.biomaterials.2006.09.047
  19. D. Quintanar-Guerrero, E. Allemann and E. Doelker, Colloid Polym. Sci. 275, 640 (1997). doi:10.1007/s003960050130
  20. N. Anton, J. P. Benoit and P. Saulnier, J. Controlled Release 128, 185 (2008). doi:10.1016/j.jconrel.2008.02.007
  21. A. Aumelas, A. Serrero, A. Durand, E. Dellacherie and M. Leonard, Colloids Surf. B 59, 74 (2007). doi:10.1016/j.colsurfb.2007.04.021
  22. B. K. Kim, D. Kim, S. H. Cho and S. H. Yuk, J. Microencapsulation 21, 697 (2004). doi:10.1080/02652040400000520
  23. S. W. Choi, H. Y. Kwon, W. S. Kim and J. H. Kim, Colloids Surf. A 201, 283 (2002). doi:10.1016/S09277757(01)01042-1
  24. F. Gu, L. Zhang, B. A. Teply, N. Mann, A. Wang, A. F. Radovic-Moreno, R. Langer and O. C. Farokhzad, Proc. Natl. Acad. Sci. U. S. A. 105, 2586 (2008). doi:10.1073/pnas.0711714105
  25. C. Passirani, G. Barratt, J. P. Devissaguet and D. Labarre, Pharm. Res. 15, 1046 (1998). doi:10.1023/A:1011930127562
  26. N. Csaba, L. González, A. Sánchez and M. J. Alonso, J. Biomater. Sci. Polym. Ed. 1137 (2004). doi:10.1163/1568562041753098
  27. B. Jiang, L. Hu, C. Gao and J. Shen, Int. J. Pharm. 304, 220 (2005). doi:10.1016/j.ijpharm.2005.08.008
  28. M. A. Casadei, F. Cerreto, S. Cesa, M. Giannuzzo, M. Feeney, C. Marianecci and P. Paolicelli, Int. J. Pharm. 325, 140 (2006). doi:10.1016/j.ijpharm.2006.06.012
  29. M. Feng, P. Li, J. Biomed. Mater. Res. Part A 80, 184 (2007). doi:10.1002/jbm.a.30882
  30. A. Sheikh Hasan, M. Socha, A. Lamprecht, F. E. Ghazouani, A. Sapin, M. Hoffman, P. Maincent and N. Ubrich, Int. J. Pharm. 344, 53 (2007). doi:10.1016/j.ijpharm.2007.05.066
  31. F. Alexis, Polym. Int. 54, 36 (2005). doi:10.1002/pi.1697
  32. N. Faisant, J. Siepmann and J. P. Benoit, Eur. J. Pharm. Sci. 15, 355 (2002). doi:10.1016/S0928-0987(02)00023-4
  33. J. Siepmann and F. Siepmann, Int. J. Pharm. 364, 328 (2008). doi:10.1016/j.ijpharm.2008.09.004
  34. B. S. Zolnik, P. E. Leary and D. J. Burgess, J. Controlled Release 112, 293 (2006). doi:10.1016/j.jconrel.2006.02.015
  35. E. Vega, F. Gamisans, M. L. Garcia, A. Chauvet, F. Lacoulonche and M. A. Egea, J. Pharm. Sci. 97, 5306 (2008). doi:10.1002/jps.21383
  36. Y. Javadzadeh, F. Ahadi, S. Davaran, G. Mohammadi, A. Sabzevari and K. Adibkia, Colloids Surf. B 81, 498 (2010). doi:10.1016/j.colsurfb.2010.07.047
  37. D. Klose, F. Siepmann, K. Elkharraz and J. Siepmann, Int. J. Pharm. 354, 95 (2008). doi:10.1016/j.ijpharm.2007.10.030
  38. W. J. Cho, J. H. Kim, S. H. Oh, H. H. Nam, J. M. Kim and J. H. Lee, J. Biomed. Mater. Res., Part A 91, 400 (2009) doi:10.1002/jbm.a.32264
  39. R. E. Eliaz and J. Kost, J. Biomed. Mater. Res. 50, 388 (2000).
  40. A. Aubert-Pouëssel, M. C. Venier-Julienne, P. Saulnier, M. Sergent and J. P. Benoît, Pharm. Res. 21, 2384 (2004). doi:10.1007/s11095-004-7693-3
  41. D. Allhenn and A. Lamprecht, Pharm. Res. (2010). doi:10.1007/s11095-010-0304-6
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