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Vol. 12 (2020)

Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window

https://doi.org/10.1007/s40820-020-0378-6
Xunzhi Wu
Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China
Yongkuan Suo
Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China
Hui Shi
Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China
Ruiqi Liu
Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China
Fengxia Wu
Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China
Tingzhong Wang
Department of Neurosurgery, The Fourth Affiliated Hospital of China Medical University, Shenyang 110000, People’s Republic of China
Lina Ma
Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130000, People’s Republic of China
Hongguang Liu
Institute of Molecular Medicine, College of Life and Health Sciences, Northeastern University, Shenyang 110000, People’s Republic of China
Zhen Cheng
Molecular Imaging Program at Stanford, Stanford University, Palo Alto, CA 94301, USA

Corresponding Author: Zhen Cheng

zcheng@stanford.edu

Nano-Micro Letters, Vol. 12 (2020), Article Number: 38

Abstract

Photothermal therapy (PTT) using near-infrared (NIR) light for tumor treatment has triggered extensive attentions because of its advantages of noninvasion and convenience. The current research on PTT usually uses lasers in the first NIR window (NIR-I; 700–900 nm) as irradiation source. However, the second NIR window (NIR-II; 1000–1700 nm) especially NIR-IIa window (1300–1400 nm) is considered much more promising in diagnosis and treatment as its superiority in penetration depth and maximum permissible exposure over NIR-I window. Hereby, we propose the use of laser excitation at 1275 nm, which is approved by Food and Drug Administration for physical therapy, as an attractive technique for PTT to balance of tissue absorption and scattering with water absorption. Specifically, CuS-PEG nanoparticles with similar absorption values at 1275 and 808 nm, a conventional NIR-I window for PTT, were synthesized as PTT agents and a comparison platform, to explore the potential of 1275 and 808 nm lasers for PTT, especially in deep-tissue settings. The results showed that 1275 nm laser was practicable in PTT. It exhibited much more desirable outcomes in cell ablation in vitro and deep-tissue antitumor capabilities in vivo compared to that of 808 nm laser. NIR-IIa laser illumination is superior to NIR-I laser for deep-tissue PTT, and shows high potential to improve the PTT outcome.


Highlights:


1 The laser of 1275 nm exhibited excellent ablation of tumors with 5-mm porcine muscle tissue blocking, while 808 nm laser failed.
2 Polyethylene glycol-stabilized copper sulfide nanoparticles with similar absorption efficiency at wavelength of 808 and 1275 nm were employed to compare the potential of these two lasers in deep-tissue photothermal therapy.

Keywords

Photothermal therapy Deep-tissue NIR-IIa 1275 nm laser Molecular imaging
Wu, Xunzhi, Yongkuan Suo, Hui Shi, Ruiqi Liu, Fengxia Wu, Tingzhong Wang, Lina Ma, Hongguang Liu, and Zhen Cheng. 2020. “Deep-Tissue Photothermal Therapy Using Laser Illumination at NIR-IIa Window”. Nano-Micro Letters 12 (January):38. https://doi.org/10.1007/s40820-020-0378-6.
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