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Vol. 10 No. 3 (2018)

A Plasmonic Mass Spectrometry Approach for Detection of Small Nutrients and Toxins

https://doi.org/10.1007/s40820-018-0204-6
Shu Wu
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China
Linxi Qian
Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University, Shanghai 200092, People’s Republic of China
Lin Huang
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China
Xuming Sun
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China
Haiyang Su
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China
Deepanjali D. Gurav
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China
Mawei Jiang
Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University, Shanghai 200092, People’s Republic of China
Wei Cai
Xinhua Hospital, Shanghai Institute for Pediatric Research, Shanghai Jiao Tong University, Shanghai 200092, People’s Republic of China
Kun Qian
School of Biomedical Engineering, Med-X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China

Corresponding Author: Kun Qian

k.qian@sjtu.edu.cn

Nano-Micro Letters, Vol. 10 No. 3 (2018), Article Number: 52

Abstract

Nutriology relies on advanced analytical tools to study the molecular compositions of food and provide key information on sample quality/safety. Small nutrients detection is challenging due to the high diversity and broad dynamic range of molecules in food samples, and a further issue is to track low abundance toxins. Herein, we developed a novel plasmonic matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS) approach to detect small nutrients and toxins in complex biological emulsion samples. Silver nanoshells (SiO2@Ag) with optimized structures were used as matrices and achieved direct analysis of ~ 6 nL of human breast milk without any enrichment or separation. We performed identification and quantitation of small nutrients and toxins with limit-of-detection down to 0.4 pmol (for melamine) and reaction time shortened to minutes, which is superior to the conventional biochemical method currently in use. The developed approach contributes to the near-future application of MALDI MS in a broad field and personalized design of plasmonic materials for real-case bio-analysis.


Highlights:


1 New materials-based methods. Sensitive detection of small nutrients and toxins (~ pmol) was performed based on plasmonic nanoparticles.
2 Advanced analytical performance. Fast quantitation and identification of target molecules (in minutes) were directly achieved in complex emulsion samples.

Keywords

Plasmonic materials Laser desorption/ionization Mass spectrometry Small nutrients Toxins
Wu, Shu, Linxi Qian, Lin Huang, Xuming Sun, Haiyang Su, Deepanjali D. Gurav, Mawei Jiang, Wei Cai, and Kun Qian. 2018. “A Plasmonic Mass Spectrometry Approach for Detection of Small Nutrients and Toxins”. Nano-Micro Letters 10 (3):52. https://doi.org/10.1007/s40820-018-0204-6.
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References
  1. M. Gallo, P. Ferranti, The evolution of analytical chemistry methods in foodomics. J. Chromatogr. A 1428, 3–15 (2016). https://doi.org/10.1016/j.chroma.2015.09.007
  2. R.J. McGorrin, One hundred years of progress in food analysis. J. Agric. Food Chem. 57(18), 8076–8088 (2009). https://doi.org/10.1021/jf900189s
  3. J.H. Cummings, A.M. Stephen, Carbohydrate terminology and classification. Eur. J. Clin. Nutr. 61, S5–S18 (2007). https://doi.org/10.1038/sj.ejcn.1602936
  4. W.J. Craig, A.R. Mangels, Ada, Position of the American dietetic association: vegetarian diets. J. Am. Diet. Assoc. 109(7), 1266–1282 (2009). https://doi.org/10.1016/j.jada.2009.05.027
  5. J.E. Arsenault, K.H. Brown, Effects of protein or amino-acid supplementation on the physical growth of young children in low-income countries. Nutr. Rev. 75(9), 699–717 (2017). https://doi.org/10.1093/nutrit/nux027
  6. J.R. Ingelfinger, Melamine and the global implications of food contamination. N. Engl. J. Med. 359(26), 2745–2748 (2008). https://doi.org/10.1056/NEJMp0808410
  7. H.M. Lam, J. Remais, M.C. Fung, L. Xu, S.S.M. Sun, Food supply and food safety issues in China. Lancet 381(9882), 2044–2053 (2013). https://doi.org/10.1016/S0140-6736(13)60776-X
  8. X. Sun, J.J. Wan, K. Qian, Designed microdevices for in vitro diagnostics. Small Methods 1(10), 1700196 (2017). https://doi.org/10.1002/smtd.201700196
  9. H.V. Botitsi, S.D. Garbis, A. Economou, D.F. Tsipi, Current mass spectrometry strategies for the analysis of pesticides and their metabolites in food and water materices. Mass Spectrom. Rev. 30(5), 907–939 (2011). https://doi.org/10.1002/mas.20307
  10. M. Herrero, C. Simo, V. Garcia-Canas, E. Ibanez, A. Cifuentes, Foodomics: MS-based strategies in modern food science and nutrition. Mass Spectrom. Rev. 31(1), 49–69 (2012). https://doi.org/10.1002/mas.20335
  11. V. Kasicka, Recent developments in capillary and microchip electroseparations of peptides (2013–middle 2015). Electrophoresis 37(1), 162–188 (2016). https://doi.org/10.1002/elps.201500329
  12. C. Rejeeth, X. Pang, R. Zhang, W. Xu, X. Sun et al., Extraction, detection, and profiling of serum biomarkers using designed Fe3O4@SiO2@HA core–shell particles. Nano Res. 11(1), 68–79 (2018). https://doi.org/10.1007/s12274-017-1591-6
  13. B. Liu, Y. Li, H. Wan, L. Wang, W. Xu et al., High performance, multiplexed lung cancer biomarker detection on a plasmonic gold chip. Adv. Funct. Mater. 26(44), 7994–8002 (2016). https://doi.org/10.1002/adfm.201603547
  14. R. Zenobi, Single-cell metabolomics: analytical and biological perspectives. Science 342(6163), 1243259 (2013). https://doi.org/10.1126/science.1243259
  15. L. Huang, J. Wan, X. Wei, Y. Liu, J. Huang et al., Plasmonic silver nanoshells for drug and metabolite detection. Nat. Commun. 8, 220 (2017). https://doi.org/10.1038/s41467-017-00220-4
  16. Y. Li, L. Yan, Y. Liu, K. Qian, B. Liu, P. Yang, B. Liu, High-efficiency nano/micro-reactors for protein analysis. RSC Adv. 5(2), 1331–1342 (2015). https://doi.org/10.1039/c4ra12333f
  17. M. Karas, D. Bachmann, U. Bahr, F. Hillenkamp, Matrix-assisted ultraviolet laser desorption of non-volatile compounds. Int. J. Mass Spectrom. Ion Process. 78, 53–68 (1987). https://doi.org/10.1016/0168-1176(87)87041-6
  18. K. Wu, J. Chen, J.R. McBride, T. Lian, Efficient hot-electron transfer by a plasmon-induced interfacial charge-transfer transition. Science 349(6248), 632–635 (2015). https://doi.org/10.1126/science.aac5443
  19. M.L. Brongersma, N.J. Halas, P. Nordlander, Plasmon-induced hot carrier science and technology. Nat. Nanotechnol. 10(1), 25–34 (2015). https://doi.org/10.1038/nnano.2014.311
  20. C. Lei, K. Qian, O. Noonan, A. Nouwensa, C. Yu, Applications of nanomaterials in mass spectrometry analysis. Nanoscale 5(24), 12033–12042 (2013). https://doi.org/10.1039/c3nr04194h
  21. I. Ocsoy, B. Gulbakan, M.I. Shukoor, X. Xiong, T. Chen, D.H. Powell, W. Tan, Aptamer-conjugated multifunctional nanoflowers as a platform for targeting, capture, and detection in laser desorption ionization mass spectrometry. ACS Nano 7(1), 417–427 (2013). https://doi.org/10.1021/nn304458m
  22. Y.C. Liu, C.K. Chiang, H.T. Chang, Y.F. Lee, C.C. Huang, Using a functional nanogold membrane coupled with laser desorption/ionization mass spectrometry to detect lead ions in biofluids. Adv. Funct. Mater. 21(23), 4448–4455 (2011). https://doi.org/10.1002/adfm.201101248
  23. K. Qian, L. Zhou, J. Liu, J. Yang, H. Xu et al., Laser engineered graphene paper for mass spectrometry imaging. Sci. Rep. 3, 1415 (2013). https://doi.org/10.1038/srep01415
  24. T. Liu, L. Qu, K. Qian, J. Liu, Q. Zhang, L. Liu, S. Liu, Raspberry-like hollow carbon nanospheres with enhanced matrix-free peptide detection profiles. Chem. Commun. 52(8), 1709–1712 (2016). https://doi.org/10.1039/c5cc07912h
  25. G. Lim, Z. Chen, J. Clark, R.G.S. Goh, W. Ng, H. Tan, R.H. Friend, P.K.H. Ho, L. Chua, Giant broadband nonlinear optical absorption response in dispersed graphene single sheets. Nat. Photonics 5(9), 554–560 (2011). https://doi.org/10.1038/nphoton.2011.177
  26. Y. Hu, K. Qian, P. Yuan, Y. Wang, C. Yu, Synthesis of large-pore periodic mesoporous organosilica. Mater. Lett. 65(1), 21–23 (2011). https://doi.org/10.1016/j.matlet.2010.08.078
  27. S.A. Stopka, C. Rong, A.R. Korte, S. Yadavilli, J. Nazarian, T.T. Razunguzwa, N.J. Morris, A. Vertes, Molecular imaging of biological samples on nanophotonic laser desorption ionization platforms. Angew. Chem. Int. Ed. 55(14), 4482–4486 (2016). https://doi.org/10.1002/anie.201511691
  28. K.P. Law, J.R. Larkin, Recent advances in SALDI-MS techniques and their chemical and bioanalytical applications. Anal. Bioanal. Chem. 399(8), 2597–2622 (2011). https://doi.org/10.1007/s00216-010-4063-3
  29. X. Wei, Z. Liu, X. Jin, L. Huang, D.D. Gurav, X. Sun, B. Liu, J. Ye, K. Qian, Plasmonic nanoshells enhanced laser desorption/ionization mass spectrometry for detection of serum metabolites. Anal. Chim. Acta 950, 147–155 (2017). https://doi.org/10.1016/j.aca.2016.11.017
  30. J. Gan, X. Wei, Y. Li, J. Wu, K. Qian, B. Liu, Designer SiO2@Au nanoshells towards sensitive and selective detection of small molecules in laser desorption ionization mass spectrometry. Nanomedicine 11(7), 1715–1723 (2015). https://doi.org/10.1016/j.nano.2015.06.010
  31. C.K. Chiang, W.T. Chen, H.T. Chang, Nanoparticle-based mass spectrometry for the analysis of biomolecules. Chem. Soc. Rev. 40(3), 1269–1281 (2011). https://doi.org/10.1039/c0cs00050g
  32. J. Wu, X. Wei, J.R. Gan, L. Huang, T. Shen, J.T. Lou, B.H. Liu, J.X.J. Zhang, K. Qian, Multifunctional magnetic particles for combined circulating tumor cells isolation and cellular metabolism detection. Adv. Funct. Mater. 26(22), 4016–4025 (2016). https://doi.org/10.1002/adfm.201504184
  33. X. Sun, L. Huang, R. Zhang, W. Xu, J. Huang et al., Metabolic fingerprinting on a plasmonic gold chip for mass spectrometry based in vitro diagnostics. ACS Cent. Sci. 4(2), 223–229 (2018). https://doi.org/10.1021/acscentsci.7b00546
  34. W. Stöber, A. Fink, E. Bohn, Controlled growth of monodisperse silica spheres in the micron size range. J. Colloid Interface Sci. 26(1), 62–69 (1968). https://doi.org/10.1016/0021-9797(68)90272-5
  35. P.C. Lee, D. Meisel, Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J. Phys. Chem. 86(17), 3391–3395 (1982). https://doi.org/10.1021/j100214a025
  36. K. Fujioka, T. Shibamoto, Quantitation of volatiles and nonvolatile acids in an extract from coffee beverages: correlation with antioxidant activity. J. Agric. Food Chem. 54(16), 6054–6058 (2006). https://doi.org/10.1021/jf060460x
  37. F. Rincon, B. Martinez, J.M. Delgado, Detection of factors influencing nitrite determination in meat. Meat Sci. 65(4), 1421–1427 (2003). https://doi.org/10.1016/s0309-1740(03)00065-2
  38. Z. Deng, M. Chen, L. Wu, Novel method to fabricate SiO2/Ag composite spheres and their catalytic, surface-enhanced Raman scattering properties. J. Phys. Chem. C 111(31), 11692–11698 (2007). https://doi.org/10.1021/jp073632h
  39. Y. Cai, X. Piao, W. Gao, Z. Zhang, E. Nie, Z. Sun, Large-scale and facile synthesis of silver nanoparticles via a microwave method for a conductive pen. RSC Adv. 7(54), 34041–34048 (2017). https://doi.org/10.1039/c7ra05125e
  40. W. Zhang, Y. Liu, R. Cao, Z. Li, Y. Zhang, Y. Tang, K. Fan, Synergy between crystal strain and surface energy in morphological evolution of five-fold-twinned silver crystals. J. Am. Chem. Soc. 130(46), 15581–15588 (2008). https://doi.org/10.1021/ja805606q
  41. S.H. Yu, X.J. Cui, L.L. Li, K. Li, B. Yu, M. Antonietti, H. Colfen, From starch to metal/carbon hybrid nanostructures: hydrothermal metal-catalyzed carbonization. Adv. Mater. 16(18), 1636–1640 (2004). https://doi.org/10.1002/adma.200400522
  42. S.A. Mcluckey, A.E. Schoen, R.G. Cooks, Silver ion affinities of alcohols as ordered by mass spectrometry/mass spectrometry. J. Am. Chem. Soc. 104(3), 848–850 (1982). https://doi.org/10.1021/ja00367a035
  43. D. Zakett, A.E. Schoen, R.G. Cooks, P.H. Hemberger, Laser-desorption mass spectrometry/mass spectrometry and the mechanism of desorption ionization. J. Am. Chem. Soc. 12(25), 1295–1297 (1981). https://doi.org/10.1021/ja00395a086
  44. L.I. Grace, A. Abo-Riziq, M.S. de Vries, An in situ silver cationization method for hydrocarbon mass spectrometry. J. Am. Soc. Mass Spectrom. 16(4), 437–440 (2005). https://doi.org/10.1016/j.jasms.2004.12.011
  45. A.U. Jackson, T. Shum, E. Sokol, A. Dill, R.G. Cooks, Enhanced detection of olefins using ambient ionization mass spectrometry: Ag+ adducts of biologically relevant alkenes. Anal. Bioanal. Chem. 399(1), 367–376 (2011). https://doi.org/10.1007/s00216-010-4349-5
  46. K. Qian, W. Gu, P. Yuan, F. Liu, Y. Wang, M. Monteiro, C. Yu, Enrichment and detection of peptides from biological systems using designed periodic mesoporous organosilica microspheres. Small 8(2), 231–236 (2012). https://doi.org/10.1002/smll.201101770
  47. K. Qian, F. Liu, J. Yang, X. Huang, W. Gu, S. Jambhrunkar, P. Yuan, C. Yu, Pore size-optimized periodic mesoporous organosilicas for the enrichment of peptides and polymers. RSC Adv. 3(34), 14466–14472 (2013). https://doi.org/10.1039/c3ra41332b
  48. A. Trani, G. Gambacorta, P. Loizzo, A. Cassone, C. Fasciano, A.V. Zambrini, M. Faccia, Comparison of HPLC-RI, LC/MS-MS and enzymatic assays for the analysis of residual lactose in lactose-free milk. Food Chem. 233, 385–390 (2017). https://doi.org/10.1016/j.foodchem.2017.04.134
  49. L. Li, B.X. Li, Sensitive and selective detection of cysteine using gold nanoparticles as colorimetric probes. Analyst 134(7), 1361–1365 (2009). https://doi.org/10.1039/b819842j
  50. X. Liang, H. Wei, Z. Cui, J. Deng, Z. Zhang, X. You, X.E. Zhang, Colorimetric detection of melamine in complex matrices based on cysteamine-modified gold nanoparticles. Analyst 136(1), 179–183 (2011). https://doi.org/10.1039/c0an00432d
  51. S. Zhang, Z. Yu, N. Hu, Y. Sun, Y. Suo, J. You, Sensitive determination of melamine leached from tableware by reversed phase high-performance liquid chromatography using 10-methyl-acridone-2-sulfonyl chloride as a pre-column fluorescent labeling reagent. Food Control 39, 25–29 (2014). https://doi.org/10.1016/j.foodcont.2013.10.037
  52. H. Miao, S. Fan, Y.N. Wu, L. Zhang, P.P. Zhou, J.G. Li, H.J. Chen, Y.F. Zhao, Simultaneous determination of melamine, ammelide, ammeline, and cyanuric acid in milk and milk products by gas chromatography-tandem mass spectrometry. Biomed. Environ. Sci. 22(2), 87–94 (2009). https://doi.org/10.1016/S0895-3988(09)60027-1
  53. A. Desmarchelier, M.G. Cuadra, T. Delatour, P. Mottier, Simultaneous quantitative determination of melamine and cyanuric acid in cow’s milk and milk-based infant formula by liquid chromatography–electrospray ionization tandem mass spectrometry. J. Agric. Food Chem. 57(16), 7186–7193 (2009). https://doi.org/10.1021/jf901355v
  54. S. Yang, J. Ding, J. Zheng, B. Hu, J. Li, H. Chen, Z. Zhou, X. Qiao, Detection of melamine in milk products by surface desorption atmospheric pressure chemical ionization mass spectrometry. Anal. Chem. 81(7), 2426–2436 (2009). https://doi.org/10.1021/ac900063u
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