Issue

Vol. 10 No. 1 (2018)

Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery

https://doi.org/10.1007/s40820-017-0155-3
Guilan Li
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Yidan Chen
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Lingyu Zhang
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Manjie Zhang
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Shengnan Li
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Lu Li
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Tingting Wang
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, People’s Republic of China
Chungang Wang
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China

Corresponding Author: Chungang Wang

wangcg925@nenu.edu.cn

Nano-Micro Letters, Vol. 10 No. 1 (2018), Article Number: 7

Abstract

A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk–shell nanoparticles (NPs) composed with a PAA/CaP shell and an AuNR yolk is reported. The as-obtained AuNR@PAA/CaP yolk–shell NPs possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the CaP shell at low pH values. When the DOX-loaded AuNR@PAA/CaP yolk–shell NPs were exposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the AuNRs. Furthermore, AuNR@PAA/CaP yolk–shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.


Highlights:


1 We report a facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk–shell nanoparticles.
2 The as-obtained AuNR@PAA/CaP yolk–shell nanoparticles (NPs) possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance, which were employed for synergic dual-mode X-ray computed tomography (CT)/photoacoustic (PA) imaging and chemo-photothermal cancer therapy.
3 This work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.

Keywords

Yolk–shell structure Calcium phosphate Dual-mode imaging Photothermal therapy Drug delivery
Li, Guilan, Yidan Chen, Lingyu Zhang, Manjie Zhang, Shengnan Li, Lu Li, Tingting Wang, and Chungang Wang. 2017. “Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery”. Nano-Micro Letters 10 (1):7. https://doi.org/10.1007/s40820-017-0155-3.
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. Q. Chen, Z. Liu, Albumin carriers for cancer theranostics: a conventional platform with new promise. Adv. Mater. 28(47), 10557–10566 (2016). doi:10.1002/adma.201600038
  2. L. Li, L.Y. Zhang, T.T. Wang, X.T. Wu, H. Ren, C.G. Wang, Z.M. Su, Facile and scalable synthesis of novel spherical Au nanocluster assemblies@polyacrylic acid/calcium phosphate nanoparticles for dual-modal imaging-guided cancer chemotherapy. Small 11(26), 3162–3173 (2015). doi:10.1002/smll.201403517
  3. Z.J. Zhang, J. Wang, C.Y. Chen, Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv. Mater. 25(28), 3869–3880 (2013). doi:10.1002/adma.201301890
  4. X. Ding, J.H. Liu, J.Q. Li, F. Wang, Y.H. Wang, S.Y. Song, H.J. Zhang, Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy. Chem. Sci. 7(11), 6695–6700 (2016). doi:10.1039/C6SC01320A
  5. S. Panesar, S. Neethirajan, Microfluidics: rapid diagnosis for breast cancer. Nano-Micro Lett. 8(3), 204–220 (2016). doi:10.1002/adfm.201403885
  6. A.B. Reddy, B. Manjula, T. Jayaramudu, E.R. Sadiku, P.A. Babu, S.P. Selvam, 5-Fluorouracil loaded chitosan-PVA/Na + MMT nanocomposite films for drug release and antimicrobial activity. Nano-Micro Lett. 8(3), 260–269 (2016). doi:10.1007/s40820-016-0086-410
  7. J.S. Lee, W.L. Murphy, Functionalizing calcium phosphate biomaterials with antibacterial silver particles. Adv. Mater. 25(8), 1173–1179 (2013). doi:10.1002/adma.201203370
  8. X. Li, X.P. Wang, Y. Sogo, T. Ohno, K. Onuma, A. Ito, Mesoporous silica-calcium phosphate-tuberculin purified protein derivative composites as an effective adjuvant for cancer immunotherapy. Adv. Healthc. Mater. 2(6), 863–871 (2013). doi:10.1002/adhm.201200149
  9. P. Shi, K.G. Qu, J.S. Wang, M. Li, J.S. Ren, X.G. Qu, pH-responsive NIR enhanced drug release from gold nanocages possesses high potency against cancer cells. Chem. Commun. 48(61), 7640–7642 (2012). doi:10.1039/c2cc33543c
  10. C.Y. Wang, L.Y. Zhang, S.N. Li, M.J. Zhang, T.T. Wang, L. Li, C.G. Wang, Z.M. Su, A designed synthesis of multifunctional Fe3O4@carbon/zinc phosphate nanoparticles for simultaneous imaging and synergic chemo-photothermal cancer therapy. J. Mater. Chem. B 4(35), 5809–5813 (2016). doi:10.1039/C6TB01669C
  11. M. Nakamura, A. Oyane, Physicochemical fabrication of calcium phosphate-based thin layers and nanospheres using laser processing in solutions. J. Mater. Chem. B 4(38), 6289–6301 (2016). doi:10.1039/C6TB01362G
  12. W.M. Li, S.Y. Chen, D.M. Liu, In situ doxorubicin-CaP shell formation on amphiphilic gelatin-iron oxide core as a multifunctional drug delivery system with improved cytocompatibility, pH-responsive drug release and MR imaging. Acta Biomater. 9(2), 5360–5368 (2013). doi:10.1016/j.actbio.2012.09.023
  13. X.J. Chen, M.J. Zhang, S.N. Li, L. Li, L.Y. Zhang, T.T. Wang, M. Yu, Z.C. Mou, C.G. Wang, Facile synthesis of polypyrrole@metal-organic framework core–shell nanocomposites for dual-mode imaging and synergistic chemo-photothermal therapy of cancer cells. J. Mater. Chem. B 5, 1772–1778 (2017). doi:10.1039/C6TB03218D
  14. M.M. Sun, F. Liu, Y.K. Zhu, W.S. Wang, J. Hu et al., Salt-induced aggregation of gold nanoparticles for photoacoustic imaging and photothermal therapy of cancer. Nanoscale 8(8), 4452–4457 (2016). doi:10.1039/C6NR00056H
  15. P. Huang, P.F. Rong, J. Lin, W.W. Li, X.F. Yan et al., Triphase interface synthesis of plasmonic gold bellflowers as near-infrared light mediated acoustic and thermal theranostics. J. Am. Chem. Soc. 136(23), 8307–8313 (2014). doi:10.1021/ja503115n
  16. A. Li, X. Li, X.J. Yu, W. Li, R.Y. Zhao, X. An, D.X. Cui, X.Y. Chen, W.W. Li, Synergistic thermoradiotherapy based on PEGylated Cu3BiS3 ternary semiconductor nanorods with strong absorption in the second near-infrared window. Biomaterials 112, 164–175 (2017). doi:10.1016/j.biomaterials.2016.10.024
  17. L. Guo, G.L. Niu, X.L. Zheng, J.C. Ge, W.M. Liu, Q.Y. Jia, P.P. Zhang, H.Y. Zhang, P.F. Wang, Single near-infrared emissive polymer nanoparticles as versatile phototheranostics. Adv. Sci. (2017). doi:10.1002/advs.201700085
  18. S.Y. Shi, Y.J. Liu, Y. Chen, Z.H. Zhang, Y.S. Ding, Z.Q. Wu, J. Yin, L.M. Nie, Versatile pH-response micelles with high cell-penetrating helical diblock copolymers for photoacoustic imaging guided synergistic chemo-photothermal therapy. Theranostics 6(12), 2170–2182 (2016). doi:10.7150/thno.16633
  19. Y.Y. Li, C.H. Jiang, D.W. Zhang, Y. Wang, X.Y. Ren, K.L. Ai, X.S. Chen, L.H. Ru, Targeted polydopamine nanoparticles enable photoacoustic imaging guided chemo-photothermal synergistic therapy of tumor. Acta Biomater. 47, 124–134 (2017). doi:10.1016/j.actbio.2016.10.010
  20. W.W. Li, P.F. Rong, K. Yang, P. Huang, K. Sun, X.Y. Chen, Semimetal nanomaterials of antimony as highly efficient agent for photoacoustic imaging and photothermal therapy. Biomaterials 45, 18–26 (2015). doi:10.1016/j.biomaterials.2014.12.037
  21. J. Liu, P.Y. Wang, X. Zhang, L.M. Wang, D.L. Wang et al., Rapid degradation and high renal clearance of Cu3BiS3 nanodots for efficient cancer diagnosis and photothermal therapy in vivo. ACS Nano 10(4), 4587–4598 (2016). doi:10.1021/acsnano.6b00745
  22. S. Duan, Y.J. Yang, C.L. Zhang, N.N. Zhao, F.J. Xu, NIR-responsive polycationic gatekeeper-cloaked hetero-nanoparticles for multimodal imaging-guided triple-combination therapy of cancer. Small 13(9), 1603133–1603142 (2017). doi:10.1002/smll.201603133
  23. J.B. Qin, Z.Y. Peng, B. Li, K.C. Ye, Y.X. Zhang et al., Gold nanorods as a theranostic platform for in vitro and in vivo imaging and photothermal therapy of inflammatory macrophages. Nanoscale 7(33), 13991–14001 (2015). doi:10.1039/C5NR02521D
  24. F. Gao, L.Y. Bai, S.Y. Liu, R.C. Zhang, J.T. Zhang, X.H. Feng, Y.J. Zheng, Y.L. Zhao, Rationally encapsulated gold nanorods improving both linear and nonlinear photoacoustic imaging contrast in vivo. Nanoscale 9, 79–86 (2017). doi:10.1039/C6NR07528B
  25. J.B. Song, X.Y. Yang, O. Jacobson, P. Huang, X.L. Sun et al., Ultrasmall gold nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy. Adv. Mater. 27(33), 4910–4917 (2015). doi:10.1002/adma.201502486
  26. G.F. Luo, W.H. Chen, Q. Lei, W.X. Qiu, Y.X. Liu, Y.J. Cheng, X.Z. Zhang, A triple-collaborative strategy for high-performance tumor therapy by multifunctional mesoporous silica-coated gold nanorods. Adv. Funct. Mater. 26(24), 4339–4350 (2016). doi:10.1002/adfm.201505175
  27. A. Khanal, C. Ullum, C.W. Kimbrough, N.C. Garbett, J.A. Burlison et al., Tumor targeted mesoporous silica-coated gold nanorods facilitate detection of pancreatic tumors using multispectral optoacoustic tomography. Nano Res. 8(12), 3864–3877 (2015). doi:10.1007/s12274-015-0886-8
  28. J.V. Jokerst, A.J. Cole, D.S.D. Van, S.S. Gambhir, Gold nanorods for ovarian cancer detection with photoacoustic imaging and resection guidance via Raman imaging in living mice. ACS Nano 6(11), 10366–10377 (2012). doi:10.1021/nn304347g
  29. P. Huang, L. Bao, C. Zhang, J. Lin, T. Luo et al., Folic acid-conjugated silica-modified gold nanorods for X-ray/CT imaging-guided dual-mode radiation and photo-thermal therapy. Biomaterials 32(36), 9796–9809 (2011). doi:10.1016/j.biomaterials.2011.08.086
  30. J. Wu, Y. Liu, Y.X. Tang, S.J. Wang, C.Y. Wang et al., Synergistic chemo-photothermal therapy of breast cancer by mesenchymal stem cell-encapsulated yolk–shell GNR@HPMO-PTX nanospheres. ACS Appl. Mater. Interfaces. 8(28), 17927–17935 (2016). doi:10.1021/acsami.6b05677
  31. Y.F. Zhu, J.L. Shi, W.H. Shen, X.P. Dong, J.W. Feng, M.L. Ruan, Y.S. Li, Stimuli-responsive controlled drug release from a hollow mesoporous silica sphere/polyelectrolyte multilayer core–shell structure. Angew. Chem. Int. Ed. 44(42), 5083–5087 (2015). doi:10.1002/anie.200501500
  32. J. Gao, G. Liang, B. Zhang, Y. Kuang, X. Zhang, B. Xu, FePt@CoS2 yolk–shell nanocrystals as a potent agent to kill HeLa cells. J. Am. Chem. Soc. 129(5), 1428–1433 (2007). doi:10.1021/ja067785e
  33. J. Kim, H.S. Kim, N. Lee, T. Kim, H. Kim, T. Yu, I.C. Song, W.K. Moon, T. Hyeon, Multifunctional uniform nanoparticles composed of a magnetite nanocrystal core and a mesoporous silica shell for magnetic resonance and fluorescence imaging and for drug delivery. Angew. Chem. Int. Ed. 47(44), 8438–8441 (2008). doi:10.1002/anie.200802469
  34. H. Wu, G. Liu, S. Zhang, J. Shi, L. Zhang, Y. Chen, F. Chen, H. Chen, Biocompatibility, MR imaging and targeted drug delivery of a rattle-type magnetic mesoporous silica nanosphere system conjugated with PEG and cancer-cell-specific ligands. J. Mater. Chem. 21(9), 3037–3045 (2011). doi:10.1039/c0jm02863k
  35. J. Liu, S.Z. Qiao, S.B. Hartono, G.Q. Lu, Monodisperse yolk–shell nanoparticles with a hierarchical porous structure for delivery vehicles and nanoreactors. Angew. Chem. Int. Ed. 49(29), 4981–4985 (2010). doi:10.1002/anie.201001252
  36. S.X. Li, J.Z. Zheng, D.J. Chen, Y.J. Wu, W.X. Zhang, F.Y. Zheng, J. Cao, H.R. Ma, Y.L. Liu, Yolk–shell hybrid nanoparticles with magnetic and pH-sensitive properties for controlled anticancer drug delivery. Nanoscale 5(23), 11718–11724 (2013). doi:10.1039/c3nr04032a
  37. L. Zhao, J. Peng, Q. Huang, C. Li, M. Chen, Y. Sun, Q. Lin, L. Zhu, F. Li, Near-infrared photoregulated drug release in living tumor tissue via yolk–shell upconversion nanocages. Adv. Funct. Mater. 24(3), 363–371 (2014). doi:10.1002/adfm.201302133
  38. H. Wu, G.Y. Zheng, N. Liu, T.J. Carney, Y. Yang, Y. Cui, Engineering empty space between Si nanoparticles for lithium-ion battery anodes. Nano Lett. 12(2), 904–909 (2012). doi:10.1021/nl203967r
  39. C. Guan, X.H. Wang, Q. Zhang, Z.X. Fan, H. Zhang, H.J. Fan, Highly stable and reversible lithium storage in SnO2 nanowires surface coated with a uniform hollow shell by atomic layer deposition. Nano Lett. 14(8), 4852–4858 (2014). doi:10.1021/nl502192p
  40. Z.Y. Cai, L. Xu, M.Y. Yan, C.H. Han, L. He et al., Manganese oxide/carbon yolk–shell nanorod anodes for high capacity lithium batteries. Nano Lett. 15(1), 738–744 (2015). doi:10.1021/nl504427d
  41. Q.Y. Li, F. Wang, L.Q. Sun, Z. Jiang, T. Ye et al., Design and synthesis of Cu@CuS yolk–shell structures with enhanced photocatalytic activity. Nano-Micro Lett. 9, 35 (2017). doi:10.1007/s40820-017-0135-7
  42. X.J. Yang, X. Liu, Z. Liu, F. Pu, J.S. Ren, X.G. Qu, Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles. Adv. Mater. 24(21), 2890–2895 (2012). doi:10.1002/adma.201104797
  43. J. Zuloaga, E. Prodan, P. Nordlander, Quantum plasmonics: optical properties and tunability of metallic nanorods. ACS Nano 4(9), 5269–5276 (2010). doi:10.1021/nn101589n
  44. G.A. Morrill, H.R. Kaback, E. Robbins, Effect of calcium on intracellular sodium and potassium concentrations in plant and animal cells. Nature 204(4959), 641–642 (1964). doi:10.1038/204641a0
  45. J. Michaelis, C. Hettich, J. Mlynek, V. Sandoghdar, Optical microscopy using a single-molecule light source. Nature 405(6784), 325–328 (2000). doi:10.1038/35012545
  46. T. Kim, N. Lee, D.R. Arifin, I. Shats, M. Janowski, P. Walczak, T. Hyeon, J.W.M. Bulte, In vivo micro-CT imaging of human mesenchymal stem cells labeled with gold-poly-l-Lysine nanocomplexes. Adv. Funct. Mater. 27(3), 1604213–1604220 (2016). doi:10.1002/adfm.201604213
  47. X. Li, C. Wang, H. Tan, L.L. Cheng, G.B. Liu et al., Gold nanoparticles-based SPECT/CT imaging probe targeting for vulnerable atherosclerosis plaques original research article. Biomaterials 108, 71–80 (2016). doi:10.1016/j.biomaterials.2016.08.048
Read More
Author biographies are not available.
Download this PDF file
PDF SUPPLEMENTARY MATERIAL
Statistic
Read Counter : 3531 Download : 2681

Most read articles by the same author(s)