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Vol. 10 No. 1 (2018)

Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery

https://doi.org/10.1007/s40820-017-0155-3
Guilan Li
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Yidan Chen
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Lingyu Zhang
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Manjie Zhang
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Shengnan Li
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Lu Li
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China
Tingting Wang
School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, People’s Republic of China
Chungang Wang
Faculty of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China

Corresponding Author: Chungang Wang

wangcg925@nenu.edu.cn

Nano-Micro Letters, Vol. 10 No. 1 (2018), Article Number: 7

Abstract

A facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk–shell nanoparticles (NPs) composed with a PAA/CaP shell and an AuNR yolk is reported. The as-obtained AuNR@PAA/CaP yolk–shell NPs possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance. The released DOX continuously increased due to the damage of the CaP shell at low pH values. When the DOX-loaded AuNR@PAA/CaP yolk–shell NPs were exposed to NIR irradiation, a burst-like drug release occurs owing to the heat produced by the AuNRs. Furthermore, AuNR@PAA/CaP yolk–shell NPs are successfully employed for synergic dual-mode X-ray computed tomography/photoacoustic imaging and chemo-photothermal cancer therapy. Therefore, this work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.


Highlights:


1 We report a facile strategy to fabricate gold nanorod@polyacrylic acid/calcium phosphate (AuNR@PAA/CaP) yolk–shell nanoparticles.
2 The as-obtained AuNR@PAA/CaP yolk–shell nanoparticles (NPs) possess ultrahigh doxorubicin (DOX) loading capability (1 mg DOX/mg NPs), superior photothermal conversion property (26%) and pH/near-infrared (NIR) dual-responsive drug delivery performance, which were employed for synergic dual-mode X-ray computed tomography (CT)/photoacoustic (PA) imaging and chemo-photothermal cancer therapy.
3 This work brings new insights for the synthesis of multifunctional nanomaterials and extends theranostic applications.

Keywords

Yolk–shell structure Calcium phosphate Dual-mode imaging Photothermal therapy Drug delivery
Li, Guilan, Yidan Chen, Lingyu Zhang, Manjie Zhang, Shengnan Li, Lu Li, Tingting Wang, and Chungang Wang. 2017. “Facile Approach to Synthesize Gold Nanorod@Polyacrylic Acid/Calcium Phosphate Yolk–Shell Nanoparticles for Dual-Mode Imaging and pH/NIR-Responsive Drug Delivery”. Nano-Micro Letters 10 (1):7. https://doi.org/10.1007/s40820-017-0155-3.
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