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Vol. 12 (2020)

Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery

https://doi.org/10.1007/s40820-020-00447-9
Yalei Miao
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Yudian Qiu
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Mengna Zhang
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Ke Yan
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Panke Zhang
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Siyu Lu
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Zhongyi Liu
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Xiaojing Shi
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China
Xubo Zhao
Green Catalysis Center, College of Chemistry, and Laboratory Animal Center, Zhengzhou University, Zhengzhou 450001, People’s Republic of China

Corresponding Author: Xubo Zhao

xbz2016@zzu.edu.cn

Nano-Micro Letters, Vol. 12 (2020), Article Number: 124

Abstract

Molecular self-assembly is crucially fundamental to nature. However, the aqueous self-assembly of polymers is still a challenge. To achieve self-assembly of block copolymers [(polyacrylic acid–block–polyethylene glycol–block–polyacrylic acid (PAA68–b–PEG86–b–PAA68)] in an aqueous phase, manganese oxide (MnO2) is first generated to drive phase separation of the PAA block to form the PAA68–b–PEG86–b–PAA68/MnO2 polymeric assembly that exhibits a stable structure in a physiological medium. The polymeric assembly exhibits vesicular morphology with a diameter of approximately 30 nm and high doxorubicin (DOX) loading capacity of approximately 94%. The transformation from MnO2 to Mn2+ caused by endogenous glutathione (GSH) facilitates the disassembly of PAA68–b–PEG86–b–PAA68/MnO2 to enable its drug delivery at the tumor sites. The toxicity of DOX-loaded PAA68–b–PEG86–b–PAA68/MnO2 to tumor cells has been verified in vitro and in vivo. Notably, drug-loaded polymeric vesicles have been demonstrated, especially in in vivo studies, to overcome the cardiotoxicity of DOX. We expect this work to encourage the potential application of polymer self-assembly.


Highlights:


1 The formation of manganese oxide induces self-assembly of block copolymers to form polymeric vesicles.
2 The polymeric vesicles possessed strong stability and high drug loading capacity.
3 The drug-loaded polymeric vesicles have been demonstrated, especially in in vivo studies, to exhibit a higher efficacy of tumor suppression without known cardiotoxicity.

Keywords

Polymer Aqueous self-assembly Vesicles Tumor microenvironment Drug delivery system
Miao, Yalei, Yudian Qiu, Mengna Zhang, Ke Yan, Panke Zhang, Siyu Lu, Zhongyi Liu, Xiaojing Shi, and Xubo Zhao. 2020. “Aqueous Self-Assembly of Block Copolymers to Form Manganese Oxide-Based Polymeric Vesicles for Tumor Microenvironment-Activated Drug Delivery”. Nano-Micro Letters 12 (June):124. https://doi.org/10.1007/s40820-020-00447-9.
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