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Vol. 15 (2023)

A Rational Design of Metal–Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns

https://doi.org/10.1007/s40820-023-01059-9
Yonghua Tang
Department of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, People’s Republic of China
Yi Han
Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361102, People’s Republic of China
Jiachen Zhao
Department of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, People’s Republic of China
Yufei Lv
Postdoctoral Mobile Station of Basic Medical Sciences, Hengyang Medical School, Department of Ophthalmology, The First Affiliated Hospital of University of South China, University of South China, Hengyang, Hunan 421001, People’s Republic of China
Chaoyu Fan
Department of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, People’s Republic of China
Lan Zheng
Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361102, People’s Republic of China
Zhisen Zhang
Department of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, People’s Republic of China
Zuguo Liu
Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361102, People’s Republic of China
Cheng Li
Fujian Provincial Key Laboratory of Ophthalmology and Visual Science & Ocular Surface and Corneal Diseases, Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen 361102, People’s Republic of China
Youhui Lin
Department of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, People’s Republic of China

Corresponding Author: Youhui Lin

linyouhui@xmu.edu.cn

Nano-Micro Letters, Vol. 15 (2023), Article Number: 112

Abstract

Metal–organic frameworks (MOFs) have attracted significant research interest in biomimetic catalysis. However, the modulation of the activity of MOFs by precisely tuning the coordination of metal nodes is still a significant challenge. Inspired by metalloenzymes with well-defined coordination structures, a series of MOFs containing halogen-coordinated copper nodes (Cu-X MOFs, X = Cl, Br, I) are employed to elucidate their structure–activity relationship. Intriguingly, experimental and theoretical results strongly support that precisely tuning the coordination of halogen atoms directly regulates the enzyme-like activities of Cu-X MOFs by influencing the spatial configuration and electronic structure of the Cu active center. The optimal Cu–Cl MOF exhibits excellent superoxide dismutase-like activity with a specific activity one order of magnitude higher than the reported Cu-based nanozymes. More importantly, by performing enzyme-mimicking catalysis, the Cu–Cl MOF nanozyme can significantly scavenge reactive oxygen species and alleviate oxidative stress, thus effectively relieving ocular chemical burns. Mechanistically, the antioxidant and antiapoptotic properties of Cu–Cl MOF are achieved by regulating the NRF2 and JNK or P38 MAPK pathways. Our work provides a novel way to refine MOF nanozymes by directly engineering the coordination microenvironment and, more significantly, demonstrating their potential therapeutic effect in ophthalmic disease.


Highlights:


1 Inspired by metalloenzymes with well-defined coordination structures, a series of Cu-X metal–organic frameworks (MOFs) nanozymes with tunable copper active centers were successfully constructed.
2 Experimental and theoretical results strongly supported that precisely tuning the coordination of halogen atoms could directly regulate the enzyme-like activities of Cu-X MOFs by influencing their spatial configuration and electronic structure.
3 The optimal Cu–Cl MOF with excellent enzyme-mimicking activities could effectively relieve ocular chemical burns by possible antioxidant and antiapoptotic mechanisms.

Keywords

Metal–organic frameworks nanozyme Superoxide dismutase Halogen Chemical ocular burn Corneal diseases
Tang, Yonghua, Yi Han, Jiachen Zhao, Yufei Lv, Chaoyu Fan, Lan Zheng, Zhisen Zhang, Zuguo Liu, Cheng Li, and Youhui Lin. 2023. “A Rational Design of Metal–Organic Framework Nanozyme With High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns”. Nano-Micro Letters 15 (April):112. https://doi.org/10.1007/s40820-023-01059-9.
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