Issue

Vol. 17 (2025)

Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment

https://doi.org/10.1007/s40820-025-01666-8
Mengyao Yang
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China
Xin Wang
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China
Mengke Peng
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China
Fei Wang
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China
Senlin Hou
The Second Hospital of Hebei Medical University, Shijiazhuang 050000, People’s Republic of China
Ruirui Xing
State Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China
Aibing Chen
College of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, People’s Republic of China

Corresponding Author: Aibing Chen

chen_ab@163.com

Nano-Micro Letters, Vol. 17 (2025), Article Number: 157

Abstract

Sonodynamic therapy (SDT) as an emerging modality for malignant tumors mainly involves in sonosensitizers and low-intensity ultrasound (US), which can safely penetrate the tissue without significant attenuation. SDT not only has the advantages including high precision, non-invasiveness, and minimal side effects, but also overcomes the limitation of low penetration of light to deep tumors. The cytotoxic reactive oxygen species can be produced by the utilization of sonosensitizers combined with US and kill tumor cells. However, the underlying mechanism of SDT has not been elucidated, and its unsatisfactory efficiency retards its further clinical application. Herein, we shed light on the main mechanisms of SDT and the types of sonosensitizers, including organic sonosensitizers and inorganic sonosensitizers. Due to the development of nanotechnology, many novel nanoplatforms are utilized in this arisen field to solve the barriers of sonosensitizers and enable continuous innovation. This review also highlights the potential advantages of nanosonosensitizers and focus on the enhanced efficiency of SDT based on nanosonosensitizers with monotherapy or synergistic therapy for deep tumors that are difficult to reach by traditional treatment, especially orthotopic cancers.


Highlights:
1 The main mechanisms and clinical potential of sonodynamic therapy are emphasized.
2 The nanomaterials provide new prospects and development directions for enhancing the treatment of cancer.
3 Recent developments of sonodynamic therapy for deep tumors that are difficult to reach by traditional treatment, especially orthotopic cancers.


 

Keywords

Sonodynamic therapy Nanosonosensitizers Tumor accumulation Surmounting the hypoxia Orthotopic tumor
Yang, Mengyao, Xin Wang, Mengke Peng, Fei Wang, Senlin Hou, Ruirui Xing, and Aibing Chen. 2025. “Nanomaterials Enhanced Sonodynamic Therapy for Multiple Tumor Treatment”. Nano-Micro Letters 17 (February):157. https://doi.org/10.1007/s40820-025-01666-8.
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. F. Bray, M. Laversanne, E. Weiderpass, I. Soerjomataram, The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer 127, 3029–3030 (2021). https://doi.org/10.1002/cncr.33587
  2. X. Zhang, L. Cheng, Y. Lu, J. Tang, Q. Lv et al., A MXene-based bionic cascaded-enzyme nanoreactor for tumor phototherapy/enzyme dynamic therapy and hypoxia-activated chemotherapy. Nano-Micro Lett. 14, 22 (2021). https://doi.org/10.1007/s40820-021-00761-w
  3. H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer J. Clin. 71, 209–249 (2021). https://doi.org/10.3322/caac.21660
  4. V.-N. Nguyen, T.N.T. Dao, M. Cho, H. Jeong, M.-T. Nguyen-Le et al., Recent advances in extracellular vesicle-based organic nanotherapeutic drugs for precision cancer therapy. Coord. Chem. Rev. 479, 215006 (2023). https://doi.org/10.1016/j.ccr.2022.215006
  5. C. Holohan, S. Van Schaeybroeck, D.B. Longley, P.G. Johnston, Cancer drug resistance: an evolving paradigm. Nat. Rev. Cancer 13, 714–726 (2013). https://doi.org/10.1038/nrc3599
  6. L. Cai, P. Zhu, F. Huan, J. Wang, L. Zhou et al., Toxicity-attenuated mesoporous silica Schiff-base bonded anticancer drug complexes for chemotherapy of drug resistant cancer. Colloids Surf. B Biointerfaces 205, 111839 (2021). https://doi.org/10.1016/j.colsurfb.2021.111839
  7. Y.-Y. Zhao, H. Kim, V.-N. Nguyen, S. Jang, W.J. Jang et al., Recent advances and prospects in organic molecule-based phototheranostic agents for enhanced cancer phototherapy. Coord. Chem. Rev. 501, 215560 (2024). https://doi.org/10.1016/j.ccr.2023.215560
  8. Y. Gao, Y. Liu, X. Li, H. Wang, Y. Yang et al., A stable open-shell conjugated diradical polymer with ultra-high photothermal conversion efficiency for NIR-II photo-immunotherapy of metastatic tumor. Nano-Micro Lett. 16, 21 (2023). https://doi.org/10.1007/s40820-023-01219-x
  9. Z. Xie, T. Fan, J. An, W. Choi, Y. Duo et al., Emerging combination strategies with phototherapy in cancer nanomedicine. Chem. Soc. Rev. 49, 8065–8087 (2020). https://doi.org/10.1039/d0cs00215a
  10. M. Yang, Z. Özdemir, H. Kim, S. Nah, E. Andris et al., Acid-responsive nanoporphyrin evolution for near-infrared fluorescence-guided photo-ablation of biofilm. Adv. Healthc. Mater. 11, e2200529 (2022). https://doi.org/10.1002/adhm.202200529
  11. L. Jin, S. Zhou, T. Zhang, F. Cui, H. Yu et al., A multi-functional cascade nanoreactor for remodeling tumor microenvironment to realize mitochondria dysfunction via ROS/Zn2+ ions overload. Small 2408639 (2024). https://doi.org/10.1002/smll.202408639
  12. M. Yang, X. Li, G. Kim, R. Wang, S.-J. Hong et al., A J-aggregated nanoporphyrin overcoming phototoxic side effects in superior phototherapy with two-pronged effects. Chem. Sci. 13, 12738–12746 (2022). https://doi.org/10.1039/d2sc04873f
  13. Z. Xie, Y. Duo, T. Fan, Y. Zhu, S. Feng et al., Light-induced tumor theranostics based on chemical-exfoliated borophene. Light Sci. Appl. 11, 324 (2022). https://doi.org/10.1038/s41377-022-00980-9
  14. M. Yang, X. Li, J. Yoon, Activatable supramolecular photosensitizers: advanced design strategies. Mater. Chem. Front. 5, 1683–1693 (2021). https://doi.org/10.1039/D0QM00827C
  15. R. Chang, Q. Zou, L. Zhao, Y. Liu, R. Xing et al., Amino-acid-encoded supramolecular photothermal nanomedicine for enhanced cancer therapy. Adv. Mater. 34, 2200139 (2022). https://doi.org/10.1002/adma.202200139
  16. J. Zou, J. Zhu, Z. Yang, L. Li, W. Fan et al., A phototheranostic strategy to continuously deliver singlet oxygen in the dark and hypoxic tumor microenvironment. Angew. Chem. Int. Ed. 59, 8833–8838 (2020). https://doi.org/10.1002/anie.201914384
  17. M. Li, Y. Shao, J.H. Kim, Z. Pu, X. Zhao et al., Unimolecular photodynamic O2-economizer to overcome hypoxia resistance in phototherapeutics. J. Am. Chem. Soc. 142, 5380–5388 (2020). https://doi.org/10.1021/jacs.0c00734
  18. M. Tavakkoli Yaraki, B. Liu, Y.N. Tan, Emerging strategies in enhancing singlet oxygen generation of nano-photosensitizers toward advanced phototherapy. Nano-Micro Lett. 14, 123 (2022). https://doi.org/10.1007/s40820-022-00856-y
  19. R. Li, T. Yang, X. Peng, Q. Feng, Y. Hou et al., Enhancing the photosensitivity of hypocrellin a by perylene diimide metallacage-based host-guest complexation for photodynamic therapy. Nano-Micro Lett. 16, 226 (2024). https://doi.org/10.1007/s40820-024-01438-w
  20. S. Li, R. Chang, L. Zhao, R. Xing, J.C.M. van Hest et al., Two-photon nanoprobes based on bioorganic nanoarchitectonics with a photo-oxidation enhanced emission mechanism. Nat. Commun. 14, 5227 (2023). https://doi.org/10.1038/s41467-023-40897-4
  21. P. Agostinis, K. Berg, K.A. Cengel, T.H. Foster, A.W. Girotti et al., Photodynamic therapy of cancer: an update. CA A Cancer J. Clin. 61, 250–281 (2011). https://doi.org/10.3322/caac.20114
  22. H. Yang, R. Liu, Y. Xu, L. Qian, Z. Dai, Photosensitizer nanops boost photodynamic therapy for pancreatic cancer treatment. Nano-Micro Lett. 13, 35 (2021). https://doi.org/10.1007/s40820-020-00561-8
  23. R. Chang, L. Zhao, R. Xing, J. Li, X. Yan, Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications. Chem. Soc. Rev. 52, 2688–2712 (2023). https://doi.org/10.1039/d2cs00675h
  24. X. Pang, D. Li, J. Zhu, J. Cheng, G. Liu, Beyond antibiotics: photo/sonodynamic approaches for bacterial theranostics. Nano-Micro Lett. 12, 144 (2020). https://doi.org/10.1007/s40820-020-00485-3
  25. J. Ouyang, A. Xie, J. Zhou, R. Liu, L. Wang et al., Minimally invasive nanomedicine: nanotechnology in photo-/ ultrasound-/ radiation-/ magnetism-mediated therapy and imaging. Chem. Soc. Rev. 51, 4996–5041 (2022). https://doi.org/10.1039/d1cs01148k
  26. C. Firschke, J.R. Lindner, N.C. Goodman, D.M. Skyba, K. Wei et al., Myocardial contrast echocardiography in acute myocardial infarction using aortic root injections of microbubbles in conjunction with harmonic imaging: potential application in the cardiac catheterization laboratory. J. Am. Coll. Cardiol. 29, 207–216 (1997). https://doi.org/10.1016/S0735-1097(96)00426-3
  27. G. Salomon, J. Köllerman, I. Thederan, F.K.H. Chun, L. Budäus et al., Evaluation of prostate cancer detection with ultrasound real-time elastography: a comparison with step section pathological analysis after radical prostatectomy. Eur. Urol. 54, 1354–1362 (2008). https://doi.org/10.1016/j.eururo.2008.02.035
  28. S.-I. Umemura, N. Yumita, R. Nishigaki, K. Umemura, Sonochemical activation of hematoporphyrin: a potential modality for cancer treatment. In: Proceedings., IEEE Ultrasonics Symposium. October 3-6, 1989, Montreal, QC, Canada. IEEE, (1989)., 955–960
  29. S. Umemura, K. Kawabata, N. Yumita, R. Nishigaki, K. Umemura, Sonodynamic approach to tumor treatment. In: IEEE 1992 Ultrasonics Symposium Proceedings. October 20-23, 1992, Tucson, AZ, USA. IEEE, (2002)., 1231–1240.
  30. R. Canaparo, F. Foglietta, N. Barbero, L. Serpe, The promising interplay between sonodynamic therapy and nanomedicine. Adv. Drug Deliv. Rev. 189, 114495 (2022). https://doi.org/10.1016/j.addr.2022.114495
  31. Z. Gong, Z. Dai, Design and challenges of sonodynamic therapy system for cancer theranostics: from equipment to sensitizers. Adv. Sci. 8, 2002178 (2021). https://doi.org/10.1002/advs.202002178
  32. X. Lin, J. Song, X. Chen, H. Yang, Ultrasound-activated sensitizers and applications. Angew. Chem. Int. Ed. 59, 14212–14233 (2020). https://doi.org/10.1002/anie.201906823
  33. S. Sun, M. Wu, Sonodynamic therapy: another “light” in tumor treatment by exogenous stimulus. Smart Mater. Med. 2, 145–149 (2021). https://doi.org/10.1016/j.smaim.2021.05.001
  34. Y. Zhu, G. Arkin, T. He, F. Guo, L. Zhang et al., Ultrasound imaging guided targeted sonodynamic therapy enhanced by magnetophoretically controlled magnetic microbubbles. Int. J. Pharm. 655, 124015 (2024). https://doi.org/10.1016/j.ijpharm.2024.124015
  35. C. McEwan, H. Nesbitt, D. Nicholas, O.N. Kavanagh, K. McKenna et al., Comparing the efficacy of photodynamic and sonodynamic therapy in non-melanoma and melanoma skin cancer. Bioorg. Med. Chem. 24, 3023–3028 (2016). https://doi.org/10.1016/j.bmc.2016.05.015
  36. Z. Jiang, W. Xiao, Q. Fu, Stimuli responsive nanosonosensitizers for sonodynamic therapy. J. Control. Release 361, 547–567 (2023). https://doi.org/10.1016/j.jconrel.2023.08.003
  37. S. Liang, X. Deng, P.-A. Ma, Z. Cheng, J. Lin, Recent advances in nanomaterial-assisted combinational sonodynamic cancer therapy. Adv. Mater. 32, 2003214 (2020). https://doi.org/10.1002/adma.202003214
  38. S. Liang, J. Yao, D. Liu, L. Rao, X. Chen et al., Harnessing nanomaterials for cancer sonodynamic immunotherapy. Adv. Mater. 35, 2211130 (2023). https://doi.org/10.1002/adma.202211130
  39. D.F. Quail, J.A. Joyce, Microenvironmental regulation of tumor progression and metastasis. Nat. Med. 19, 1423–1437 (2013). https://doi.org/10.1038/nm.3394
  40. L. Li, Z. Yu, J. Liu, M. Yang, G. Shi et al., Swarming responsive photonic nanorobots for motile-targeting microenvironmental mapping and mapping-guided photothermal treatment. Nano-Micro Lett. 15, 141 (2023). https://doi.org/10.1007/s40820-023-01095-5
  41. Y. Zhang, X. Zhang, H. Yang, L. Yu, Y. Xu et al., Advanced biotechnology-assisted precise sonodynamic therapy. Chem. Soc. Rev. 50, 11227–11248 (2021). https://doi.org/10.1039/d1cs00403d
  42. M. Xu, L. Zhou, L. Zheng, Q. Zhou, K. Liu et al., Sonodynamic therapy-derived multimodal synergistic cancer therapy. Cancer Lett. 497, 229–242 (2021). https://doi.org/10.1016/j.canlet.2020.10.037
  43. S. Li, W. Zhang, R. Xing, C. Yuan, H. Xue et al., Supramolecular nanofibrils formed by coassembly of clinically approved drugs for tumor photothermal immunotherapy. Adv. Mater. 33, e2100595 (2021). https://doi.org/10.1002/adma.202100595
  44. R. Xing, Q. Zou, C. Yuan, L. Zhao, R. Chang et al., Self-assembling endogenous biliverdin as a versatile near-infrared photothermal nanoagent for cancer theranostics. Adv. Mater. 31, e1900822 (2019). https://doi.org/10.1002/adma.201900822
  45. H. Wang, Q. Liu, K. Zhang, P. Wang, Q. Xue et al., Comparison between sonodynamic and photodynamic effect on MDA-MB-231 cells. J. Photochem. Photobiol. B. 127, 182–191 (2013). https://doi.org/10.1016/j.jphotobiol.2013.08.015
  46. W. Qin, Q. Yang, C. Zhu, R. Jiao, X. Lin et al., A distinctive insight into inorganic sonosensitizers: design principles and application domains. Small 20, 2311228 (2024). https://doi.org/10.1002/smll.202311228
  47. X. Wang, X. Zhong, F. Gong, Y. Chao, L. Cheng, Newly developed strategies for improving sonodynamic therapy. Mater. Horiz. 7, 2028–2046 (2020). https://doi.org/10.1039/d0mh00613k
  48. R. Wang, Q. Liu, A. Gao, N. Tang, Q. Zhang et al., Recent developments of sonodynamic therapy in antibacterial application. Nanoscale 14, 12999–13017 (2022). https://doi.org/10.1039/d2nr01847k
  49. P. Tharkar, R. Varanasi, W.S.F. Wong, C.T. Jin, W. Chrzanowski, Nano-enhanced drug delivery and therapeutic ultrasound for cancer treatment and beyond. Front. Bioeng. Biotechnol. 7, 324 (2019). https://doi.org/10.3389/fbioe.2019.00324
  50. X. Qian, Y. Zheng, Y. Chen, Micro/nanop-augmented sonodynamic therapy (SDT): breaking the depth shallow of photoactivation. Adv. Mater. 28, 8097–8129 (2016). https://doi.org/10.1002/adma.201602012
  51. Y. He, D. Xing, S. Tan, Y. Tang, K.-I. Ueda, In vivo sonoluminescence imaging with the assistance of FCLA. Phys. Med. Biol. 47, 1535–1541 (2002). https://doi.org/10.1088/0031-9155/47/9/308
  52. Y. Yin, X. Jiang, L. Sun, H. Li, C. Su et al., Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma. Nano Today 36, 101009 (2021). https://doi.org/10.1016/j.nantod.2020.101009
  53. L. Fan, A. Idris Muhammad, B. Bilyaminu Ismail, D. Liu, Sonodynamic antimicrobial chemotherapy: an emerging alternative strategy for microbial inactivation. Ultrason Sonochem 75, 105591 (2021). https://doi.org/10.1016/j.ultsonch.2021.105591
  54. C. McEwan, S. Kamila, J. Owen, H. Nesbitt, B. Callan et al., Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle. Biomaterials 80, 20–32 (2016). https://doi.org/10.1016/j.biomaterials.2015.11.033
  55. I. Rosenthal, J.Z. Sostaric, P. Riesz, Sonodynamic therapy: a review of the synergistic effects of drugs and ultrasound. Ultrason. Sonochem. 11, 349–363 (2004). https://doi.org/10.1016/j.ultsonch.2004.03.004
  56. Y. Tang, L. Ge, L. Jiang, X. Jiang, Pore-enhanced reactive oxygen species generation by using covalent organic frameworks for improving sonodynamic therapy of cancer. Nano Today 55, 102166 (2024). https://doi.org/10.1016/j.nantod.2024.102166
  57. G.Y. Wan, Y. Liu, B.W. Chen, Y.Y. Liu, Y.S. Wang et al., Recent advances of sonodynamic therapy in cancer treatment. Cancer Biol. Med. 13, 325–338 (2016). https://doi.org/10.20892/j.issn.2095-3941.2016.0068
  58. S. Liao, M. Cai, R. Zhu, T. Fu, Y. Du et al., Antitumor effect of photodynamic therapy/sonodynamic therapy/sono-photodynamic therapy of chlorin e6 and other applications. Mol. Pharm. 20, 875–885 (2023). https://doi.org/10.1021/acs.molpharmaceut.2c00824
  59. X. Xing, S. Zhao, T. Xu, L. Huang, Y. Zhang et al., Advances and perspectives in organic sonosensitizers for sonodynamic therapy. Coord. Chem. Rev. 445, 214087 (2021). https://doi.org/10.1016/j.ccr.2021.214087
  60. H. Chen, X. Zhou, Y. Gao, B. Zheng, F. Tang et al., Recent progress in development of new sonosensitizers for sonodynamic cancer therapy. Drug Discov. Today 19, 502–509 (2014). https://doi.org/10.1016/j.drudis.2014.01.010
  61. S. Son, J.H. Kim, X. Wang, C. Zhang, S.A. Yoon et al., Multifunctional sonosensitizers in sonodynamic cancer therapy. Chem. Soc. Rev. 49, 3244–3261 (2020). https://doi.org/10.1039/c9cs00648f
  62. M. Zhang, D. Yang, C. Dong, H. Huang, G. Feng et al., Two-dimensional MXene-originated in situ nanosonosensitizer generation for augmented and synergistic sonodynamic tumor nanotherapy. ACS Nano 16, 9938–9952 (2022). https://doi.org/10.1021/acsnano.2c04630
  63. B. Geng, J. Hu, Y. Li, S. Feng, D. Pan et al., Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy. Nat. Commun. 13, 5735 (2022). https://doi.org/10.1038/s41467-022-33474-8
  64. L.A. Osminkina, A.A. Kudryavtsev, S.V. Zinovyev, A.P. Sviridov, Y.V. Kargina et al., Silicon nanops as amplifiers of the ultrasonic effect in sonodynamic therapy. Bull. Exp. Biol. Med. 161, 296–299 (2016). https://doi.org/10.1007/s10517-016-3399-x
  65. J. Zhu, A. Ouyang, Z. Shen, Z. Pan, S. Banerjee et al., Sonodynamic cancer therapy by novel iridium-gold nanoassemblies. Chin. Chem. Lett. 33, 1907–1912 (2022). https://doi.org/10.1016/j.cclet.2021.11.017
  66. L. Raspagliesi, A. D’Ammando, M. Gionso, N.D. Sheybani, M.B. Lopes et al., Intracranial sonodynamic therapy with 5-aminolevulinic acid and sodium fluorescein: safety study in a porcine model. Front. Oncol. 11, 679989 (2021). https://doi.org/10.3389/fonc.2021.679989
  67. X. Zhang, C. Li, Y. Zhang, X. Guan, L. Mei et al., Construction of long-wavelength emissive organic nanosonosensitizer targeting mitochondria for precise and efficient in vivo sonotherapy. Adv. Funct. Mater. 32, 2207259 (2022). https://doi.org/10.1002/adfm.202207259
  68. H.B. Cheng, H. Dai, X. Tan, H. Li, H. Liang et al., A facile, protein-derived supramolecular theranostic strategy for multimodal-imaging-guided photodynamic and photothermal immunotherapy in vivo. Adv. Mater. 34, e2109111 (2022). https://doi.org/10.1002/adma.202109111
  69. H.-B. Cheng, X. Cao, S. Zhang, K. Zhang, Y. Cheng et al., BODIPY as a multifunctional theranostic reagent in biomedicine: self-assembly, properties, and applications. Adv. Mater. 35, 2207546 (2023). https://doi.org/10.1002/adma.202207546
  70. X. Li, X. Sun, H. Chen, X. Chen, Y. Li et al., Exploring BODIPY derivatives as sonosensitizers for anticancer sonodynamic therapy. Eur. J. Med. Chem. 264, 116035 (2024). https://doi.org/10.1016/j.ejmech.2023.116035
  71. K. Liu, Z. Jiang, F. Zhao, W. Wang, F. Jäkle et al., Triarylboron-doped acenethiophenes as organic sonosensitizers for highly efficient sonodynamic therapy with low phototoxicity. Adv. Mater. 34, e2206594 (2022). https://doi.org/10.1002/adma.202206594
  72. P.-H. Zhao, Y.-L. Wu, X.-Y. Li, L.-L. Feng, L. Zhang et al., Aggregation-enhanced sonodynamic activity of phthalocyanine–artesunate conjugates. Angew. Chem. Int. Ed. 61, e202113506 (2022). https://doi.org/10.1002/anie.202113506
  73. C. Deng, J. Zhang, F. Hu, S. Han, M. Zheng et al., A GSH-responsive prodrug with simultaneous triple-activation capacity for photodynamic/sonodynamic combination therapy with inhibited skin phototoxicity. Small 20, e2400667 (2024). https://doi.org/10.1002/smll.202400667
  74. L. Sun, P. Wang, J. Zhang, Y. Sun, S. Sun et al., Design and application of inorganic nanops for sonodynamic cancer therapy. Biomater. Sci. 9, 1945–1960 (2021). https://doi.org/10.1039/d0bm01875a
  75. Y. Zeng, Q. Ouyang, Y. Yu, L. Tan, X. Liu et al., Defective homojunction porphyrin-based metal-organic frameworks for highly efficient sonodynamic therapy. Small Methods 7, e2201248 (2023). https://doi.org/10.1002/smtd.202201248
  76. X. Wang, X. Zhong, L. Cheng, Titanium-based nanomaterials for cancer theranostics. Coord. Chem. Rev. 430, 213662 (2021). https://doi.org/10.1016/j.ccr.2020.213662
  77. F. Gong, L. Cheng, N. Yang, Y. Gong, Y. Ni et al., Preparation of TiH1.924 nanodots by liquid-phase exfoliation for enhanced sonodynamic cancer therapy. Nat. Commun. 11, 3712 (2020). https://doi.org/10.1038/s41467-020-17485-x
  78. S. Yang, X. Wang, P. He, A. Xu, G. Wang et al., Graphene quantum dots with pyrrole N and pyridine N: superior reactive oxygen species generation efficiency for metal-free sonodynamic tumor therapy. Small 17, e2004867 (2021). https://doi.org/10.1002/smll.202004867
  79. S. Kwon, H. Ko, D.G. You, K. Kataoka, J.H. Park, Nanomedicines for reactive oxygen species mediated approach: an emerging paradigm for cancer treatment. Acc. Chem. Res. 52, 1771–1782 (2019). https://doi.org/10.1021/acs.accounts.9b00136
  80. Q. Jiang, B. Qiao, X. Lin, J. Cao, N. Zhang et al., A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy. Theranostics 12, 59–75 (2022). https://doi.org/10.7150/thno.64862
  81. L. Song, X. Hou, K.F. Wong, Y. Yang, Z. Qiu et al., Gas-filled protein nanostructures as cavitation nuclei for molecule-specific sonodynamic therapy. Acta Biomater. 136, 533–545 (2021). https://doi.org/10.1016/j.actbio.2021.09.010
  82. M.A. Subhan, S.S.K. Yalamarty, N. Filipczak, F. Parveen, V.P. Torchilin, Recent advances in tumor targeting via EPR effect for cancer treatment. J. Pers. Med. 11, 571 (2021). https://doi.org/10.3390/jpm11060571
  83. F. Bosca, F. Foglietta, A. Gimenez, R. Canaparo, G. Durando et al., Exploiting lipid and polymer nanocarriers to improve the anticancer sonodynamic activity of chlorophyll. Pharmaceutics 12, 605 (2020). https://doi.org/10.3390/pharmaceutics12070605
  84. X. Li, C.-Y. Kim, S. Lee, D. Lee, H.-M. Chung et al., Nanostructured phthalocyanine assemblies with protein-driven switchable photoactivities for biophotonic imaging and therapy. J. Am. Chem. Soc. 139, 10880–10886 (2017). https://doi.org/10.1021/jacs.7b05916
  85. M. Yang, C. Zhang, R. Wang, X. Wu, H. Li et al., Cancer immunotherapy elicited by immunogenic cell death based on smart nanomaterials. Small Meth. 7, 2201381 (2023). https://doi.org/10.1002/smtd.202201381
  86. H. Chen, L. Liu, A. Ma, T. Yin, Z. Chen et al., Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer. Biomaterials 269, 120639 (2021). https://doi.org/10.1016/j.biomaterials.2020.120639
  87. W. Lei, C. Yang, Y. Wu, G. Ru, X. He et al., Nanocarriers surface engineered with cell membranes for cancer targeted chemotherapy. J. Nanobiotechnol. 20, 45 (2022). https://doi.org/10.1186/s12951-022-01251-w
  88. H. Yan, D. Shao, Y.-H. Lao, M. Li, H. Hu et al., Engineering cell membrane-based nanotherapeutics to target inflammation. Adv. Sci. 6, 1900605 (2019). https://doi.org/10.1002/advs.201900605
  89. P. Dash, A.M. Piras, M. Dash, Cell membrane coated nanocarriers - an efficient biomimetic platform for targeted therapy. J. Control. Release 327, 546–570 (2020). https://doi.org/10.1016/j.jconrel.2020.09.012
  90. Y. Zhang, J. Zhao, L. Zhang, Y. Zhao, Y. Zhang et al., A cascade nanoreactor for enhancing sonodynamic therapy on colorectal cancer via synergistic ROS augment and autophagy blockage. Nano Today 49, 101798 (2023). https://doi.org/10.1016/j.nantod.2023.101798
  91. X. Wang, M. Wu, H. Li, J. Jiang, S. Zhou et al., Enhancing penetration ability of semiconducting polymer nanops for sonodynamic therapy of large solid tumor. Adv. Sci. 9, e2104125 (2022). https://doi.org/10.1002/advs.202104125
  92. H. Li, J. Wang, H. Kim, X. Peng, J. Yoon, Activatable near-infrared versatile fluorescent and chemiluminescent dyes based on the dicyanomethylene-4H-pyran scaffold: from design to imaging and theranostics. Angew. Chem. Int. Ed. 63, e202311764 (2024). https://doi.org/10.1002/anie.202311764
  93. C. Deng, M. Zheng, S. Han, Y. Wang, J. Xin et al., GSH-activated porphyrin sonosensitizer prodrug for fluorescence imaging-guided cancer sonodynamic therapy. Adv. Funct. Mater. 33, 2300348 (2023). https://doi.org/10.1002/adfm.202300348
  94. J. Li, J. Wang, L. Xu, H. Chi, X. Liang et al., A class of activatable NIR-II photoacoustic dyes for high-contrast bioimaging. Angew. Chem. Int. Ed. 63, e202312632 (2024). https://doi.org/10.1002/anie.202312632
  95. S. Sun, D. Wang, R. Yin, P. Zhang, R. Jiang et al., A two-In-one nanoprodrug for photoacoustic imaging-guided enhanced sonodynamic therapy. Small 18, 2202558 (2022). https://doi.org/10.1002/smll.202202558
  96. F. Gong, L. Cheng, N. Yang, O. Betzer, L. Feng et al., Ultrasmall oxygen-deficient bimetallic oxide MnWOX nanops for depletion of endogenous GSH and enhanced sonodynamic cancer therapy. Adv. Mater. 31, e1900730 (2019). https://doi.org/10.1002/adma.201900730
  97. S. Li, W. Zhang, H. Xue, R. Xing, X. Yan, Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly. Chem. Sci. 11, 8644–8656 (2020). https://doi.org/10.1039/d0sc02937h
  98. X. Ren, D. Chen, Y. Wang, H. Li, Y. Zhang et al., Nanozymes-recent development and biomedical applications. J. Nanobiotechnology 20, 92 (2022). https://doi.org/10.1186/s12951-022-01295-y
  99. Y. Wang, D. Fei Gong, Z. Han, H. Lei, Y. Zhou et al., Oxygen-deficient molybdenum oxide nanosensitizers for ultrasound-enhanced cancer metalloimmunotherapy. Angew. Chem. Int. Ed. 62, e202215467 (2023). https://doi.org/10.1002/anie.202215467
  100. T. Nie, W. Zou, Z. Meng, L. Wang, T. Ying et al., Bioactive iridium nanoclusters with glutathione depletion ability for enhanced sonodynamic-triggered ferroptosis-like cancer cell death. Adv. Mater. 34, e2206286 (2022). https://doi.org/10.1002/adma.202206286
  101. Y. Duan, Y. Yu, P. Peilai Liu, Y. Gao, D. Xinyue Dai et al., Reticular chemistry-enabled sonodynamic activity of covalent organic frameworks for nanodynamic cancer therapy. Angew. Chem. Int. Ed. 62, e202302146 (2023). https://doi.org/10.1002/anie.202302146
  102. S. Zhang, S. Xia, L. Chen, Y. Chen, J. Zhou, Covalent organic framework nanobowls as activatable nanosensitizers for tumor-specific and ferroptosis-augmented sonodynamic therapy. Adv. Sci. 10, e2206009 (2023). https://doi.org/10.1002/advs.202206009
  103. P. Vaupel, F. Kallinowski, P. Okunieff, Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 49, 6449–6465 (1989). https://doi.org/10.1097/00002820-198912000-00001
  104. S. Mura, J. Nicolas, P. Couvreur, Stimuli-responsive nanocarriers for drug delivery. Nat. Mater. 12, 991–1003 (2013). https://doi.org/10.1038/nmat3776
  105. K. Yang, L. Yue, G. Yu, L. Rao, R. Tian et al., A hypoxia responsive nanoassembly for tumor specific oxygenation and enhanced sonodynamic therapy. Biomaterials 275, 120822 (2021). https://doi.org/10.1016/j.biomaterials.2021.120822
  106. X. Li, D. Lee, J.-D. Huang, J. Yoon, Phthalocyanine-assembled nanodots as photosensitizers for highly efficient Type I photoreactions in photodynamic therapy. Angew. Chem. Int. Ed. 57, 9885–9890 (2018). https://doi.org/10.1002/anie.201806551
  107. Z. Liu, Z. Yan, Y. Di, S. Yang, Y. Ning et al., Current advances in metal–organic frameworks for cancer nanodynamic therapies. Coord. Chem. Rev. 497, 215434 (2023). https://doi.org/10.1016/j.ccr.2023.215434
  108. L. Zhong, T. Yang, P. Li, L. Shi, J. Lai et al., Metal-organic framework-based nanotherapeutics with tumor hypoxia-relieving ability for synergistic sonodynamic/chemo-therapy. Front. Mater. 9, 841503 (2022). https://doi.org/10.3389/fmats.2022.841503
  109. H. Xiao, X. Li, B. Li, Y. Zhong, J. Qin et al., Sono-promoted drug penetration and extracellular matrix modulation potentiate sonodynamic therapy of pancreatic ductal adenocarcinoma. Acta Biomater. 161, 265–274 (2023). https://doi.org/10.1016/j.actbio.2023.02.038
  110. G. Li, X. Zhong, X. Wang, F. Gong, H. Lei et al., Titanium carbide nanosheets with defect structure for photothermal-enhanced sonodynamic therapy. Bioact. Mater. 8, 409–419 (2021). https://doi.org/10.1016/j.bioactmat.2021.06.021
  111. S. Liu, B. Wang, Y. Yu, Y. Liu, Z. Zhuang et al., Cationization-enhanced type I and type II ROS generation for photodynamic treatment of drug-resistant bacteria. ACS Nano 16, 9130–9141 (2022). https://doi.org/10.1021/acsnano.2c01206
  112. D. Chen, Q. Xu, W. Wang, J. Shao, W. Huang et al., Type I photosensitizers revitalizing photodynamic oncotherapy. Small 17, e2006742 (2021). https://doi.org/10.1002/smll.202006742
  113. J. Cao, Y. Sun, C. Zhang, X. Wang, Y. Zeng et al., Tablet-like TiO2/C nanocomposites for repeated type I sonodynamic therapy of pancreatic cancer. Acta Biomater. 129, 269–279 (2021). https://doi.org/10.1016/j.actbio.2021.05.029
  114. Z. Zhang, B. Li, L. Xie, W. Sang, H. Tian et al., Metal-phenolic network-enabled lactic acid consumption reverses immunosuppressive tumor microenvironment for sonodynamic therapy. ACS Nano 15, 16934–16945 (2021). https://doi.org/10.1021/acsnano.1c08026
  115. D.W. Felsher, Cancer revoked: oncogenes as therapeutic targets. Nat. Rev. Cancer 3, 375–380 (2003). https://doi.org/10.1038/nrc1070
  116. F. Cairnduff, M.R. Stringer, E.J. Hudson, D.V. Ash, S.B. Brown, Superficial photodynamic therapy with topical 5-aminolaevulinic acid for superficial primary and secondary skin cancer. Br. J. Cancer 69, 605–608 (1994). https://doi.org/10.1038/bjc.1994.112
  117. M. Zhan, F. Wang, Y. Liu, J. Zhou, W. Zhao et al., Dual-cascade activatable nanopotentiators reshaping adenosine metabolism for sono-chemodynamic-immunotherapy of deep tumors. Adv. Sci. 10, e2207200 (2023). https://doi.org/10.1002/advs.202207200
  118. T. Chen, W. Zeng, C. Tie, M. Yu, H. Hao et al., Engineered gold/black phosphorus nanoplatforms with remodeling tumor microenvironment for sonoactivated catalytic tumor theranostics. Bioact. Mater. 10, 515–525 (2021). https://doi.org/10.1016/j.bioactmat.2021.09.016
  119. T. Yamaguchi, S. Kitahara, K. Kusuda, J. Okamoto, Y. Horise et al., Current landscape of sonodynamic therapy for treating cancer. Cancers 13, 6184 (2021). https://doi.org/10.3390/cancers13246184
  120. M. Lafond, T. Lambin, R.A. Drainville, A. Dupré, M. Pioche et al., Pancreatic ductal adenocarcinoma: current and emerging therapeutic uses of focused ultrasound. Cancers 14, 2577 (2022). https://doi.org/10.3390/cancers14112577
  121. R.J. Browning, S. Able, J.-L. Ruan, L. Bau, P.D. Allen et al., Combining sonodynamic therapy with chemoradiation for the treatment of pancreatic cancer. J. Control. Release 337, 371–377 (2021). https://doi.org/10.1016/j.jconrel.2021.07.020
  122. S. Zeng, M. Pöttler, B. Lan, R. Grützmann, C. Pilarsky et al., Chemoresistance in pancreatic cancer. Int. J. Mol. Sci. 20, 4504 (2019). https://doi.org/10.3390/ijms20184504
  123. M.H. Sherman, G.L. Beatty, Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance. Annu. Rev. Pathol. Mech. Dis. 18, 123–148 (2023). https://doi.org/10.1146/annurev-pathmechdis-031621-024600
  124. T. Zhang, Y. Sun, J. Cao, J. Luo, J. Wang et al., Intrinsic nucleus-targeted ultra-small metal-organic framework for the type I sonodynamic treatment of orthotopic pancreatic carcinoma. J. Nanobiotechnol. 19, 315 (2021). https://doi.org/10.1186/s12951-021-01060-7
  125. Y. He, T. Wang, Y. Song, C. Fang, Y. Wang et al., Targeting vascular destruction by sonosensitizer-free sonocatalytic nanomissiles instigates Thrombus aggregation and nutrition deprivation to starve pancreatic cancer. Adv. Funct. Mater. 34, 2315394 (2024). https://doi.org/10.1002/adfm.202315394
  126. Z. Tang, Y. Liu, M. He, W. Bu, Chemodynamic therapy: tumour microenvironment-mediated Fenton and Fenton-like reactions. Angew. Chem. Int. Ed. 58, 946–956 (2019). https://doi.org/10.1002/anie.201805664
  127. Y. Pu, H. Yin, C. Dong, H. Xiang, W. Wu et al., Sono-controllable and ROS-sensitive CRISPR-Cas9 genome editing for augmented/synergistic ultrasound tumor nanotherapy. Adv. Mater. 33, e2104641 (2021). https://doi.org/10.1002/adma.202104641
  128. X. Zhong, X. Wang, L. Cheng, Y.-A. Tang, G. Zhan et al., GSH-depleted PtCu3 nanocages for chemodynamic- enhanced sonodynamic cancer therapy. Adv. Funct. Mater. 30, 1907954 (2020). https://doi.org/10.1002/adfm.201907954
  129. C. Fang, Z. Deng, G. Cao, Q. Chu, Y. Wu et al., Co–ferrocene MOF/glucose oxidase as cascade nanozyme for effective tumor therapy. Adv. Funct. Mater. 30, 1910085 (2020). https://doi.org/10.1002/adfm.201910085
  130. S. Liang, X. Xiao, L. Bai, B. Liu, M. Yuan et al., Conferring Ti-based MOFs with defects for enhanced sonodynamic cancer therapy. Adv. Mater. 33, e2100333 (2021). https://doi.org/10.1002/adma.202100333
  131. B. Xu, Z. Huang, Y. Liu, S. Li, H. Liu, MOF-based nanomedicines inspired by structures of natural active components. Nano Today 48, 101690 (2023). https://doi.org/10.1016/j.nantod.2022.101690
  132. Y. Sun, J. Cao, X. Wang, C. Zhang, J. Luo et al., Hypoxia-adapted sono-chemodynamic treatment of orthotopic pancreatic carcinoma using copper metal–organic frameworks loaded with an ultrasound-induced free radical initiator. ACS Appl. Mater. Interfaces 13, 38114–38126 (2021). https://doi.org/10.1021/acsami.1c11017
  133. A.D. Waldman, J.M. Fritz, M.J. Lenardo, A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nat. Rev. Immunol. 20, 651–668 (2020). https://doi.org/10.1038/s41577-020-0306-5
  134. S. Gao, X. Yang, J. Xu, N. Qiu, G. Zhai, Nanotechnology for boosting cancer immunotherapy and remodeling tumor microenvironment: the horizons in cancer treatment. ACS Nano 15, 12567–12603 (2021). https://doi.org/10.1021/acsnano.1c02103
  135. Y. Xia, S. Fu, Q. Ma, Y. Liu, N. Zhang, Application of nano-delivery systems in lymph nodes for tumor immunotherapy. Nano-Micro Lett. 15, 145 (2023). https://doi.org/10.1007/s40820-023-01125-2
  136. H. Lei, J.H. Kim, S. Son, L. Chen, Z. Pei et al., Immunosonodynamic therapy designed with activatable sonosensitizer and immune stimulant imiquimod. ACS Nano 16, 10979–10993 (2022). https://doi.org/10.1021/acsnano.2c03395
  137. T. Wang, W. Peng, M. Du, Z. Chen, Immunogenic sonodynamic therapy for inducing immunogenic cell death and activating antitumor immunity. Front. Oncol. 13, 1167105 (2023). https://doi.org/10.3389/fonc.2023.1167105
  138. H. Nesbitt, K. Logan, K. Thomas, B. Callan, J. Gao et al., Sonodynamic therapy complements PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer. Cancer Lett. 517, 88–95 (2021). https://doi.org/10.1016/j.canlet.2021.06.003
  139. M. Wu, Q. Huang, Y. Xie, X. Wu, H. Ma et al., Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation. J. Hematol. Oncol. 15, 24 (2022). https://doi.org/10.1186/s13045-022-01242-2
  140. J. Chen, L. Feng, P. Jin, J. Shen, J. Lu et al., Cavitation assisted endoplasmic reticulum targeted sonodynamic droplets to enhanced anti-PD-L1 immunotherapy in pancreatic cancer. J. Nanobiotechnology 20, 283 (2022). https://doi.org/10.1186/s12951-022-01459-w
  141. J. Li, N. Yu, D. Cui, J. Huang, Y. Luo et al., Activatable semiconducting polymer pro-nanomodulators for deep-tissue sono-immunotherapy of orthotopic pancreatic cancer. Angew. Chem. Int. Ed. 62, e202305200 (2023). https://doi.org/10.1002/anie.202305200
  142. A.C. Lai, D. Momar Toure, D. Doris Hellerschmied, J. Salami, D. Saul Jaime-Figueroa et al., Modular PROTAC design for the degradation of oncogenic BCR-ABL. Angew. Chem. Int. Ed. 55, 807–810 (2016). https://doi.org/10.1002/anie.201507634
  143. S.-M. Qi, J. Dong, Z.-Y. Xu, X.-D. Cheng, W.-D. Zhang et al., PROTAC: an effective targeted protein degradation strategy for cancer therapy. Front. Pharmacol. 12, 692574 (2021). https://doi.org/10.3389/fphar.2021.692574
  144. M. Békés, D.R. Langley, C.M. Crews, PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. 21, 181–200 (2022). https://doi.org/10.1038/s41573-021-00371-6
  145. S. He, Y. Fang, Y. Zhu, Z. Ma, G. Dong et al., Drugtamer-PROTAC conjugation strategy for targeted PROTAC delivery and synergistic antitumor therapy. Adv. Sci. 11, e2401623 (2024). https://doi.org/10.1002/advs.202401623
  146. J. Liu, H. Chen, L. Ma, Z. He, D. Wang et al., Light-induced control of protein destruction by opto-PROTAC. Sci. Adv. 6, eaay5154 (2020). https://doi.org/10.1126/sciadv.aay5154
  147. Z. Chen, L. Chen, Y. Ma, Y. Liu, Q. Zhang et al., Peptide-appended nanosonosensitizers targeting tumor glycolysis for synergistic sonodynamic-immunometabolic therapy of spinal-metastasized tumors. Adv. Mater. 35, e2304246 (2023). https://doi.org/10.1002/adma.202304246
  148. H. Tang, X. Xu, Y. Chen, H. Xin, T. Wan et al., Reprogramming the tumor microenvironment through second-near-infrared-window photothermal genome editing of PD-L1 mediated by supramolecular gold nanorods for enhanced cancer immunotherapy. Adv. Mater. 33, e2006003 (2021). https://doi.org/10.1002/adma.202006003
  149. Y. Liu, H. Wang, M. Ding, W. Yao, K. Wang et al., Ultrasound-activated PROTAC prodrugs overcome immunosuppression to actuate efficient deep-tissue sono-immunotherapy in orthotopic pancreatic tumor mouse models. Nano Lett. 24, 8741–8751 (2024). https://doi.org/10.1021/acs.nanolett.4c02287
  150. M. Li, Y. Liu, Y. Zhang, N. Yu, J. Li, Sono-activatable semiconducting polymer nanoreshapers multiply remodel tumor microenvironment for potent immunotherapy of orthotopic pancreatic cancer. Adv. Sci. 10, e2305150 (2023). https://doi.org/10.1002/advs.202305150
  151. L. Chen, W. Xue, J. Cao, S. Zhang, Y. Zeng et al., TiSe2-mediated sonodynamic and checkpoint blockade combined immunotherapy in hypoxic pancreatic cancer. J. Nanobiotechnol. 20, 453 (2022). https://doi.org/10.1186/s12951-022-01659-4
  152. X. Li, J.S. Oh, Y. Lee, E.C. Lee, M. Yang et al., Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway. Biomater. Res. 27, 23 (2023). https://doi.org/10.1186/s40824-023-00360-3
  153. H.-J. Liu, H.-M. Hu, G.-Z. Li, Y. Zhang, F. Wu et al., Ferroptosis-related gene signature predicts glioma cell death and glioma patient progression. Front. Cell Dev. Biol. 8, 538 (2020). https://doi.org/10.3389/fcell.2020.00538
  154. Y. Pan, C. Xu, H. Deng, Q. You, C. Zhao et al., Localized NIR-II laser mediated chemodynamic therapy of glioblastoma. Nano Today 43, 101435 (2022). https://doi.org/10.1016/j.nantod.2022.101435
  155. J.N. Sarkaria, L.S. Hu, I.F. Parney, D.H. Pafundi, D.H. Brinkmann et al., Is the blood–brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data. Neuro Oncol. 20, 184–191 (2018). https://doi.org/10.1093/neuonc/nox175
  156. S. Watkins, S. Robel, I.F. Kimbrough, S.M. Robert, G. Ellis-Davies et al., Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells. Nat. Commun. 5, 4196 (2014). https://doi.org/10.1038/ncomms5196
  157. X. Wang, Y. Jia, P. Wang, Q. Liu, H. Zheng, Current status and future perspectives of sonodynamic therapy in glioma treatment. Ultrason. Sonochem. 37, 592–599 (2017). https://doi.org/10.1016/j.ultsonch.2017.02.020
  158. T. Jia, J. Du, J. Yang, Y. Li, T.Y. Ohulchanskyy et al., Metalloporphyrin MOFs-based nanoagent enabling tumor microenvironment responsive sonodynamic therapy of intracranial glioma signaled by NIR-IIb luminescence imaging. Adv. Funct. Mater. 34, 2307816 (2024). https://doi.org/10.1002/adfm.202307816
  159. Y. Zhu, X. Niu, C. Ding, Y. Lin, W. Fang et al., Carrier-free self-assembly nano-sonosensitizers for sonodynamic-amplified cuproptosis-ferroptosis in glioblastoma therapy. Adv. Sci. 11, e2402516 (2024). https://doi.org/10.1002/advs.202402516
  160. F. Qu, P. Wang, K. Zhang, Y. Shi, Y. Li et al., Manipulation of Mitophagy by “All-in-One” nanosensitizer augments sonodynamic glioma therapy. Autophagy 16, 1413–1435 (2020). https://doi.org/10.1080/15548627.2019.1687210
  161. Y. Sun, H. Wang, P. Wang, K. Zhang, X. Geng et al., Tumor targeting DVDMS-nanoliposomes for an enhanced sonodynamic therapy of gliomas. Biomater. Sci. 7, 985–994 (2019). https://doi.org/10.1039/c8bm01187g
  162. V.G. Abramson, B.D. Lehmann, T.J. Ballinger, J.A. Pietenpol, Subtyping of triple-negative breast cancer: implications for therapy. Cancer 121, 8–16 (2015). https://doi.org/10.1002/cncr.28914
  163. W. Pei, Y. Li, Y. Wu, Y. Wu, L. Cai et al., A tumoricidal lipoprotein complex electrostatically stabilized on mesoporous silica as nanotherapeutics and nanoadjuvant for potentiating immunotherapy of triple negative breast cancer. Adv. Funct. Mater. 33, 2308117 (2023). https://doi.org/10.1002/adfm.202308117
  164. T. Inui, K. Makita, H. Miura, A. Matsuda, D. Kuchiike et al., Case report: a breast cancer patient treated with GcMAF, sonodynamic therapy and hormone therapy. Anticancer Res 34, 4589–4593 (2014). https://doi.org/10.1016/j.urolonc.2014.05.010
  165. Y. Li, W. Chen, Y. Kang, X. Zhen, Z. Zhou et al., Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity. Nat. Commun. 14, 6973 (2023). https://doi.org/10.1038/s41467-023-42509-7
  166. Y. Zheng, Z. Li, Y. Yang, H. Shi, H. Chen et al., A nanosensitizer self-assembled from oleanolic acid and chlorin e6 for synergistic chemo/sono-photodynamic cancer therapy. Phytomedicine 93, 153788 (2021). https://doi.org/10.1016/j.phymed.2021.153788
  167. X. Lin, T. He, R. Tang, Q. Li, N. Wu et al., Biomimetic nanoprobe-augmented triple therapy with photothermal, sonodynamic and checkpoint blockade inhibits tumor growth and metastasis. J. Nanobiotechnology 20, 80 (2022). https://doi.org/10.1186/s12951-022-01287-y
  168. G. Yuan, B. Yang, P. Chen, L. Bai, G. Qiao et al., Regulating manganese-site electronic structure via reconstituting nitrogen coordination for efficient non-oxygen-dependent sonocatalytic therapy against orthotopic breast cancer. ACS Nano 18, 27630–27641 (2024). https://doi.org/10.1021/acsnano.4c09052
Read More
Author biographies are not available.
Download this PDF file
PDF
Statistic
Read Counter : 339 Download : 258

Most read articles by the same author(s)