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Vol. 13 (2021)

Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects

https://doi.org/10.1007/s40820-020-00547-6
Junhui Yin
Institute of Microsurgery On Extremities, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
Shanshan Pan
School of Life Sciences, Shanghai University, Shanghai 200444, People’s Republic of China
Xiang Guo
Department of Orthopedics, The Second Affiliated Hospital, The Navy Medical University, Shanghai 200003, People’s Republic of China
Youshui Gao
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
Daoyu Zhu
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
Qianhao Yang
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
Junjie Gao
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
Changqing Zhang
Institute of Microsurgery On Extremities, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, People’s Republic of China
Yu Chen
School of Life Sciences, Shanghai University, Shanghai 200444, People’s Republic of China

Corresponding Author: Yu Chen

chenyuedu@shu.edu.cn

Nano-Micro Letters, Vol. 13 (2021), Article Number: 30

Abstract

Early surgical resection and chemotherapy of bone cancer are commonly used in the treatment of bone tumor, but it is still highly challenging to prevent recurrence and fill the bone defect caused by the resection site. In this work, we report a rational integration of photonic-responsive two-dimensional (2D) ultrathin niobium carbide (Nb2C) MXene nanosheets (NSs) into the 3D-printed bone-mimetic scaffolds (NBGS) for osteosarcoma treatment. The integrated 2D Nb2C-MXene NSs feature specific photonic response in the second near-infrared (NIR-II) biowindow with high tissue-penetrating depth, making it highly efficient in killing bone cancer cells. Importantly, Nb-based species released by the biodegradation of Nb2C MXene can obviously promote the neogenesis and migration of blood vessels in the defect site, which can transport more oxygen, vitamins and energy around the bone defect for the reparative process, and gather more immune cells around the defect site to accelerate the degradation of NBGS. The degradation of NBGS provides sufficient space for the bone remodeling. Besides, calcium and phosphate released during the degradation of the scaffold can promote the mineralization of new bone tissue. The intrinsic multifunctionality of killing bone tumor cell and promoting angiogenesis and bone regeneration makes the engineered Nb2C MXene-integrated composite scaffolds a distinctive implanting biomaterial on the efficient treatment of bone tumor.


Highlights:


1 2D Nb2C MXene-integrated 3D-printing scaffolds against osteosarcoma were constructed with theragenerative functionality.
2 Nb2C MXene in 3D scaffolds enabled photothermal ablation of osteosarcoma at NIR-II biowindow.
3 Nb2C MXene in 3D scaffolds promoted osteogenesis, osteoconduction and osteoinduction, and drove vascularization for bone regeneration.

Keywords

Nb2C MXene 3D printing Phototherapy Osteosarcoma Vascularization
Yin, Junhui, Shanshan Pan, Xiang Guo, Youshui Gao, Daoyu Zhu, Qianhao Yang, Junjie Gao, Changqing Zhang, and Yu Chen. 2021. “Nb2C MXene-Functionalized Scaffolds Enables Osteosarcoma Phototherapy and Angiogenesis/Osteogenesis of Bone Defects”. Nano-Micro Letters 13 (January):30. https://doi.org/10.1007/s40820-020-00547-6.
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