Issue

Vol. 10 No. 2 (2018)

Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo

https://doi.org/10.1007/s40820-017-0185-x
Wanglinhan Zhang
College of Sciences, Northeastern University, Shenyang 110004, People’s Republic of China
Linlin Zhang
College of Sciences, Northeastern University, Shenyang 110004, People’s Republic of China
Huiling Gao
College of Life and Health Sciences, Northeastern University, Shenyang 110004, People’s Republic of China
Wenyan Yang
College of Sciences, Northeastern University, Shenyang 110004, People’s Republic of China
Shuai Wang
College of Sciences, Northeastern University, Shenyang 110004, People’s Republic of China
Lili Xing
College of Sciences, Northeastern University, Shenyang 110004, People’s Republic of China
Xinyu Xue
College of Sciences, Northeastern University, Shenyang 110004, People’s Republic of China

Corresponding Author: Xinyu Xue

xuexinyu@mail.neu.edu.cn

Nano-Micro Letters, Vol. 10 No. 2 (2018), Article Number: 32

Abstract

Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment.


Highlights:


1 Self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo was fabricated.
2 The distinct interdigitated electrode ensures piezo-potential of individual nanowires in the same direction. Piezo-biosensing process does not require an external power supply. And the piezoelectric-enzyme-reaction coupling effect is proposed.
3 The device can run well in live mouse and detect in real time the glucose level.

Keywords

Diabetes Biosensor Electronic-skin Self-powered Glucose detection Implantable electronics
Zhang, Wanglinhan, Linlin Zhang, Huiling Gao, Wenyan Yang, Shuai Wang, Lili Xing, and Xinyu Xue. 2018. “Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo”. Nano-Micro Letters 10 (2):32. https://doi.org/10.1007/s40820-017-0185-x.
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