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Vol. 8 No. 3 (2016)

Trapping and Driving Individual Charged Micro-particles in Fluid with an Electrostatic Device

https://doi.org/10.1007/s40820-016-0087-3
Jingjing Xu
Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, People’s Republic of China
Zijing Lei
Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, People’s Republic of China
Jingkun Guo
Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, People’s Republic of China
Jie Huang
Institute of Microelectronics, Peking University, Beijing 100871, People’s Republic of China
Wei Wang
Institute of Microelectronics, Peking University, Beijing 100871, People’s Republic of China
Uta Reibetanz
Medical Faculty, Institute for Medical Physics and Biophysics, University of Leipzig, 04103 Leipzig, Germany
Shengyong Xu
Key Laboratory for the Physics & Chemistry of Nanodevices, and Department of Electronics, Peking University, Beijing 100871, People’s Republic of China

Corresponding Author: Shengyong Xu

xusy@pku.edu.cn

Nano-Micro Letters, Vol. 8 No. 3 (2016), Article Number: 270-281

Abstract

A variety of micro-tweezers techniques, such as optical tweezers, magnetic tweezers, and dielectrophoresis technique, have been applied intensively in precise characterization of micro/nanoparticles and bio-molecules. They have contributed remarkably in better understanding of working mechanisms of individual sub-cell organelles, proteins, and DNA. In this paper, we present a controllable electrostatic device embedded in a microchannel, which is capable of driving, trapping, and releasing charged micro-particles suspended in microfluid, demonstrating the basic concepts of electrostatic tweezers. Such a device is scalable to smaller size and offers an alternative to currently used micro-tweezers for application in sorting, selecting, manipulating, and analyzing individual micro/nanoparticles. Furthermore, the system offers the potential in being combined with dielectrophoresis and other techniques to create hybrid micro-manipulation systems.

Keywords

Electrostatic tweezers Charged particles Coulomb potential well Manipulation Trap
Xu, Jingjing, Zijing Lei, Jingkun Guo, Jie Huang, Wei Wang, Uta Reibetanz, and Shengyong Xu. 2016. “Trapping and Driving Individual Charged Micro-Particles in Fluid With an Electrostatic Device”. Nano-Micro Letters 8 (3):270-81. https://doi.org/10.1007/s40820-016-0087-3.
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References
  1. F. Dalfovo, S. Giorgini, L.P. Pitaevskii, S. Stringari, Theory of Bose-Einstein condensation in trapped gases. Rev. Mod. Phys. 71(3), 463–512 (1999). doi:10.1103/RevModPhys.71.463
  2. M.H. Anderson, J.R. Ensher, M.R. Matthews, C.E. Wieman, E.A. Cornell, Observation of bose-einstein condensation in a dilute atomic vapor. Science 269(5221), 198–201 (1995). doi:10.1126/science.269.5221.198
  3. S. Chu, Cold atoms and quantum control. Nature 416(6877), 206–210 (2002). doi:10.1038/416206a
  4. S.T. Cundiff, J. Ye, Colloquium: Femtosecond optical frequency combs. Rev. Mod. Phys. 75(1), 325–342 (2003). doi:10.1103/RevModPhys.75.325
  5. S.A. Diddams, J.C. Bergquist, S.R. Jefferts, C.W. Oates, Standards of time and frequency at the outset of the 21st century. Science 306(5700), 1318–1324 (2004). doi:10.1126/science.1102330
  6. S. Chu, Laser manipulation of atoms and particles. Science 253(5022), 861–866 (1991). doi:10.1126/science.253.5022.861
  7. J. Ye, H.J. Kimble, H. Katori, Quantum state engineering and precision metrology using state-insensitive light traps. Science 320(5884), 1734–1738 (2008). doi:10.1126/science.1148259
  8. A. Ashkin, Optical trapping and manipulation of neutral particles using lasers. Proc. Natl. Acad. Sci. USA 94(10), 4853–4860 (1997). doi:10.1073/pnas.94.10.4853
  9. W.M. Lee, X.C. Yuan, W.C. Cheong, Optical vortex beam shaping by use of highly efficient irregular spiral phase plates for optical micromanipulation. Opt. Lett. 29(15), 1796–1798 (2004). doi:10.1364/ol.29.001796
  10. S. Sato, H. Inaba, Optical trapping and manipulation of microscopic particles and biological cells by laser beams. Opt. Quant. Electron. 28(1), 1–16 (1996). doi:10.1007/bf00578546
  11. M. Andersson, O. Axner, F. Almqvist, B.E. Uhlin, E. Fallman, Physical properties of biopolymers assessed by optical tweezers: Analysis of folding and refolding of bacterial pili. ChemPhysChem 9(2), 221–235 (2008). doi:10.1002/cphc.200700389
  12. K. Norregaard, L. Jauffred, K. Berg-Sorensen, L.B. Oddershede, Optical manipulation of single molecules in the living cell. Phys. Chem. Chem. Phys. 16(25), 12614–12624 (2014). doi:10.1039/c4cp00208c
  13. S. Seeger, S. Monajembashi, K.J. Hutter, G. Futterman, J. Wolfrum, K.O. Greulich, Application of laser optical tweezers in immunology and molecular-genetics. Cytometry 12(6), 497–504 (1991). doi:10.1002/cyto.990120606
  14. P. Ben-Abdallah, A.O. El Moctar, B. Ni, N. Aubry, P. Singh, Optical manipulation of neutral nanoparticles suspended in a microfluidic channel. J. Appl. Phys. 99(9), 094303 (2006). doi:10.1063/1.2191572
  15. W.H. Zhang, L.N. Huang, C. Santschi, O.J.F. Martin, Trapping and sensing 10 nm metal nanoparticles using plasmonic dipole antennas. Nano Lett. 10(3), 1006–1011 (2010). doi:10.1021/nl904168f
  16. S. Dash, S. Mohanty, Dielectrophoretic separation of micron and submicron particles: a review. Electrophoresis 35(18), 2656–2672 (2014). doi:10.1002/elps.201400084
  17. N. Lewpiriyawong, C. Yang, AC-dielectrophoretic characterization and separation of submicron and micron particles using sidewall AgPDMS electrodes. Biomicrofluidics 6(1), 012807 (2012). doi:10.1063/1.3682049
  18. N. Markarian, M. Yeksel, B. Khusid, K.R. Farmer, A. Acrivos, Particle motions and segregation in dielectrophoretic microfluidics. J. Appl. Phys. 94(6), 4160–4169 (2003). doi:10.1063/1.1600845
  19. H.A. Pohl, I. Hawk, Separation of living and dead cells by dielectrophoresis. Science 152(3722), 647–649 (1966). doi:10.1126/science.152.3722.647-a
  20. I.F. Cheng, H.-C. Chang, D. Hou, H.-C. Chang, An integrated dielectrophoretic chip for continuous bioparticle filtering, focusing, sorting, trapping, and detecting. Biomicrofluidics 1(2), 021503 (2007). doi:10.1063/1.2723669
  21. R. Pethig, Review article-dielectrophoresis: status of the theory, technology, and applications. Biomicrofluidics 4, 022811 (2010). doi:10.1063/1.3456626
  22. C. Zhang, K. Khoshmanesh, A. Mitchell, K. Kalantar-zadeh, Dielectrophoresis for manipulation of micro/nano particles in microfluidic systems. Anal. Bioanal. Chem. 396(1), 401–420 (2010). doi:10.1007/s00216-009-2922-6
  23. W. Paul, Electromagnetic traps for charged and neutral particles. Rev. Mod. Phys. 62(3), 531–540 (1990). doi:10.1103/RevModPhys.62.531
  24. N.D. Scielzo, R.M. Yee, P.F. Bertone, F. Buchinger, S.A. Caldwell et al., A novel approach to beta-delayed neutron spectroscopy using the beta-decay Paul trap. Nucl. Data Sheets 120, 70–73 (2014). doi:10.1016/j.nds.2014.07.009
  25. Y. Rondelez, G. Tresset, T. Nakashima, Y. Kato-Yamada, H. Fujita, S. Takeuchi, H. Noji, Highly coupled ATP synthesis by F-1-ATPase single molecules. Nature 433(7027), 773–777 (2005). doi:10.1038/nature03277
  26. I. De Vlaminck, C. Dekker, Recent advances in magnetic tweezers. Annu. Rev. Biophys. 41, 453–472 (2012). doi:10.1146/annurev-biophys-122311-100544
  27. C. Liu, T. Stakenborg, S. Peeters, L. Lagae, Cell manipulation with magnetic particles toward microfluidic cytometry. J. Appl. Phys. 105, 102014 (2009). doi:10.1063/1.3116091
  28. C. Bao, L. Chen, T. Wang, C. Lei, F. Tian, D. Cui, Y. Zhou, One step quick detection of cancer cell surface marker by integrated NiFe-based magnetic biosensing cell cultural chip. Nano-Micro Lett. 5(3), 213–222 (2013). doi:10.5101/nml.v5i3.p213-222
  29. L. Yu, H. Wu, B. Wu, Z. Wang, H. Cao, C. Fu, N. Jia, Magnetic Fe3O4-reduced graphene oxide nanocomposites-based electrochemical biosensing. Nano-Micro Lett. 6(3), 258–267 (2014). doi:10.5101/nml140028a
  30. T.R. Strick, G. Charvin, N.H. Dekker, J.F. Allemand, D. Bensimon, V. Croquette, Tracking enzymatic steps of DNA topoisomerases using single-molecule micromanipulation. C. R. Phys. 3(5), 595–618 (2002). doi:10.1016/s1631-0705(02)01347-6
  31. S.Y. Xu, W.Q. Sun, M. Zhang, J. Xu, L.M. Peng, Transmission electron microscope observation of a freestanding nanocrystal in a Coulomb potential well. Nanoscale 2(2), 248–253 (2010). doi:10.1039/b9nr00144a
  32. V.P. Oleshko, J.M. Howe, Are electron tweezers possible? Ultramicroscopy 111(11), 1599–1606 (2011). doi:10.1016/j.ultramic.2011.08.015
  33. V.P. Oleshko, J.M. Howe, Advances in imaging and electron physics, vol. 179 (Elsevier Academic Press Inc., San Diego, 2013), pp. 203–262. doi:10.1016/b978-0-12-407700-3.00003-x
  34. A.A. Kayani, K. Khoshmanesh, S.A. Ward, A. Mitchell, K. Kalantar-Zadeh, Optofluidics incorporating actively controlled micro- and nano-particles. Biomicrofluidics 6(3), 32 (2012). doi:10.1063/1.4736796
  35. K. Kalantar-zadeh, J.Z. Ou, T. Daeneke, M.S. Strano, M. Pumera, S.L. Gras, Two-dimensional transition metal dichalcogenides in biosystems. Adv. Funct. Mater. 25(32), 5086–5099 (2015). doi:10.1002/adfm.201500891
  36. J. Chen, D. Chen, Y. Xie, T. Yuan, X. Chen, Progress of microfluidics for biology and medicine. Nano-Micro Lett. 5(1), 66–80 (2013). doi:10.3786/nml.v5i1.p66-80
  37. I. Artsimovitch, M.N. Vassylyeva, D. Svetlov, V. Svetlov, A. Perederina, N. Igarashi, N. Matsugaki, S. Wakatsuki, T.H. Tahirov, D.G. Vassylyev, Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins. Cell 122(3), 351–363 (2005). doi:10.1016/j.cell.2005.07.014
  38. S.J. Benkovic, S. Hammes-Schiffer, A perspective on enzyme catalysis. Science 301(5637), 1196–1202 (2003). doi:10.1126/science.1085515
  39. M. Buck, W. Cannon, Specific binding of the transcription factor Sigma-54 to promoter DNA. Nature 358(6385), 422–424 (1992). doi:10.1038/358422a0
  40. F.C. Oberstrass, S.D. Auweter, M. Erat, Y. Hargous, A. Henning, P. Wenter, L. Reymond, B. Amir-Ahmady, S. Pitsch, D.L. Black, F.H.T. Allain, Structure of PTB bound to RNA: specific binding and implications for splicing regulation. Science 309(5743), 2054–2057 (2005). doi:10.1126/science.1114066
  41. S.J. Singer, G.L. Nicolson, Fluid mosaic model of structure of cell-membranes. Science 175(4023), 720–731 (1972). doi:10.1126/science.175.4023.720
  42. T.J. Yoo, O.A. Roholt, D. Pressman, Specific binding activity of isolated light chains of antibodies. Science 157(3789), 707–709 (1967). doi:10.1126/science.157.3789.707
  43. V. Zimarino, C. Wu, Induction of sequence-specific binding of drosophila heat-shoch activator protein without protein-synthesis. Nature 327(6124), 727–730 (1987). doi:10.1038/327727a0
  44. F. Avbelj, J. Moult, Role of electrostatic screening in determining protein main-chain conformation preferences. Biochemistry 34(3), 755–764 (1995). doi:10.1021/bi00003a008
  45. A.I. Popescu, Possible specificity of cellular interaction due to electrostatic forces. Electro- Magnetobiol. 14(2), 65–74 (1995). doi:10.3109/15368379509022546
  46. A.A. Kornyshev, S. Leikin, Theory of interaction between helical molecules. J. Chem. Phys. 107(9), 3656–3674 (1997). doi:10.1063/1.475320
  47. E. Seyrek, P.L. Dubin, J. Henriksen, Nonspecific electrostatic binding characteristics of the heparin-antithrombin interaction. Biopolymers 86(3), 249–259 (2007). doi:10.1002/bip.20731
  48. M.P. Singh, J. Stefko, J.A. Lumpkin, J. Rosenblatt, The effect of electrostatic charge interactions on release rate of gentamicin from collagen matrices. Pharm. Res. 12(8), 1205–1210 (1995). doi:10.1023/a:1016272212833
  49. S. Sabri, A. Pierres, A.M. Benoliel, P. Bongrand, Influence of surface charges on cell adhesion: difference between static and dynamic conditions. Biochem. Cell Biol. 73(7–8), 411–420 (1995). doi:10.1139/o95-048
  50. I. Rouzina, V.A. Bloomfield, Competitive electrostatic binding of charged ligands to polyelectrolytes: practical approach using the non-linear Poisson-Boltzmann equation. Biophys. Chem. 64(1–3), 139–155 (1997). doi:10.1016/s0301-4622(96)02231-4
  51. A.A. Kornyshev, S. Leikin, Electrostatic interaction between helical macromolecules in dense aggregates: an impetus for DNA poly- and mesomorphism. Proc. Natl. Acad. Sci. USA 95(23), 13579–13584 (1998). doi:10.1073/pnas.95.23.13579
  52. U. Sharma, R.S. Negin, J.D. Carbeck, Effects of cooperativity in proton binding on the net charge of proteins in charge ladders. J. Phys. Chem. B 107(19), 4653–4666 (2003). doi:10.1021/jp027780d
  53. H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne, The protein data bank. Nucleic Acids Res. 28(1), 235–242 (2000). doi:10.1093/nar/28.1.235
  54. J. Gruber, A. Zawaira, R. Saunders, C.P. Barrett, M.E.M. Noble, Computational analyses of the surface properties of protein-protein interfaces. Acta Crystallogr. D 63, 50–57 (2007). doi:10.1107/s0907444906046762
  55. P. Schaefer, D. Riccardi, Q. Cui, Reliable treatment of electrostatics in combined QM/MM simulation of macromolecules. J. Chem. Phys. 123(1), 014905 (2005). doi:10.1063/1.1940047
  56. R.J. Zauhar, A. Varnek, A fast and space-efficient boundary element method for computing electrostatic and hydration effects in large molecules. J. Comput. Chem. 17(7), 864–877 (1996). doi:10.1002/(sici)1096-987x(199605)17:7<864:aid-jcc10>3.0.co;2-b
  57. M. Malinska, K.N. Jarzembska, A.M. Goral, A. Kutner, K. Wozniak, P.M. Dominiak, Sunitinib: from charge-density studies to interaction with proteins. Acta Crystallogr. D 70, 1257–1270 (2014). doi:10.1107/s1399004714002351
  58. M. Krishnan, N. Mojarad, P. Kukura, V. Sandoghdar, Geometry-induced electrostatic trapping of nanometric objects in a fluid. Nature 467(7316), 692–695 (2010). doi:10.1038/nature09404
  59. Q.W. Zhuang, W.Q. Sun, Y.L. Zheng, J.W. Xue, H.X. Liu, M. Chen, S.Y. Xu, A multilayered microfluidic system with functions for local electrical and thermal measurements. Microfluid. Nanofluid. 12(6), 963–970 (2012). doi:10.1007/s10404-011-0930-2
  60. J. Koo, C. Kleinstreuer, Impact analysis of nanoparticle motion mechanisms on the thermal conductivity of nanofluids. Int. Commun. Heat Mass 32(9), 1111–1118 (2005). doi:10.1016/j.icheatmasstransfer.2005.05.014
  61. W.B. Russel, Brownian-motion of small particles suspended in liquids. Annu. Rev. Fluid Mech. 13, 425–455 (1981). doi:10.1146/annurev.fl.13.010181.002233
  62. R. Tadmor, E. Hernandez-Zapata, N.H. Chen, P. Pincus, J.N. Israelachvili, Debye length and double-layer forces in polyelectrolyte solutions. Macromolecules 35(6), 2380–2388 (2002). doi:10.1021/ma011893y
  63. A. Ajdari, Electro-osmosis on inhomogeneously charged surfaces. Phys. Rev. Lett. 75(4), 755–758 (1995). doi:10.1103/PhysRevLett.75.755
  64. C. Kan, C. Bo, W. Jiankang, Numerical analysis of field-modulated electroosmotic flows in microchannels with arbitrary numbers and configurations of discrete electrodes. Biomed. Microdevices 12(6), 959–966 (2010). doi:10.1007/s10544-010-9450-1
  65. G.M. Mala, D.Q. Li, Flow characteristics of water in microtubes. Int. J. Heat Fluid Flow 20(2), 142–148 (1999). doi:10.1016/S0142-727X(98)10043-7
  66. Y. Demircan, E. Ozgur, H. Kulah, Dielectrophoresis: applications and future outlook in point of care. Electrophoresis 34(7), 1008–1027 (2013). doi:10.1002/elps.201200446
  67. W. Guan, J.H. Park, P.S. Krstic, M.A. Reed, Non-vanishing ponderomotive AC electrophoretic effect for particle trapping. Nanotechnology 22(24), 245103 (2011). doi:10.1088/0957-4484/22/24/245103
  68. C.-C. Chung, T. Glawdel, C.L. Ren, H.-C. Chang, Combination of ac electroosmosis and dielectrophoresis for particle manipulation on electrically-induced microscale wave structures. J. Micromech. Microeng. 25(3), 035003 (2015). doi:10.1088/0960-1317/25/3/035003
  69. T.Z. Jubery, S.K. Srivastava, P. Dutta, Dielectrophoretic separation of bioparticles in microdevices: a review. Electrophoresis 35(5), 691–713 (2014). doi:10.1002/elps.201300424
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