Issue

Vol. 15 (2023)

Tailoring Food Biopolymers into Biogels for Regenerative Wound Healing and Versatile Skin Bioelectronics

https://doi.org/10.1007/s40820-023-01099-1
Qiankun Zeng
School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco‑Restoration, East China Normal University, Shanghai 200241, People’s Republic of China
Qiwen Peng
School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco‑Restoration, East China Normal University, Shanghai 200241, People’s Republic of China
Fangbing Wang
School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco‑Restoration, East China Normal University, Shanghai 200241, People’s Republic of China
Guoyue Shi
School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco‑Restoration, East China Normal University, Shanghai 200241, People’s Republic of China
Hossam Haick
Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion - Israel Institute of Technology, 320003 Haifa, Israel
Min Zhang
School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco‑Restoration, East China Normal University, Shanghai 200241, People’s Republic of China

Corresponding Author: Min Zhang

mzhang@chem.ecnu.edu.cn

Nano-Micro Letters, Vol. 15 (2023), Article Number: 153

Abstract

An increasing utilization of wound-related therapeutic materials and skin bioelectronics urges the development of multifunctional biogels for personal therapy and health management. Nevertheless, conventional dressings and skin bioelectronics with single function, mechanical mismatches, and impracticality severely limit their widespread applications in clinical. Herein, we explore a gelling mechanism, fabrication method, and functionalization for broadly applicable food biopolymers-based biogels that unite the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single system. We combine our biogels with functional nanomaterials, such as cuttlefish ink nanoparticles and silver nanowires, to endow the biogels with reactive oxygen species scavenging capacity and electrical conductivity, and finally realized the improvement in diabetic wound microenvironment and the monitoring of electrophysiological signals on skin. This line of research work sheds light on preparing food biopolymers-based biogels with multifunctional integration of wound treatment and smart medical treatment.


Highlights:


1 This food biopolymer-based biogel unites the challenging needs of elastic yet injectable wound dressing and skin bioelectronics in a single platform.
2 This is the first demonstration of a hydrogel dressing that satisfies both deep and superficial wounds, and for the accelerated healing of diabetic wounds.
3 Biogel-based flexible skin bioelectronic can serve as a “fever indicator” and monitoring human activities and tiny electrophysiological signals, providing important clinical information for the rehabilitation training of the wounded.

Keywords

Food biopolymers Biogels Skin bioelectronics Deep wound Superficial wound
Zeng, Qiankun, Qiwen Peng, Fangbing Wang, Guoyue Shi, Hossam Haick, and Min Zhang. 2023. “Tailoring Food Biopolymers into Biogels for Regenerative Wound Healing and Versatile Skin Bioelectronics”. Nano-Micro Letters 15 (June):153. https://doi.org/10.1007/s40820-023-01099-1.
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