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Vol. 6 No. 3 (2014)

Polymeric Hydrogel Nanocapsules: A Thermo and pH Dual-responsive Carrier for Sustained Drug Release

https://doi.org/10.1007/BF03353784
Jingya Nan
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; Key Laboratory of Biomass Energy and Material, Jiangsu Province; National Engineering Laboratory for Biomass Chemical Utilization; Key and Open Laboratory on Forest Chemical Engineering, SFA, Nanjing 210042, China
Ying Chen
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; Key Laboratory of Biomass Energy and Material, Jiangsu Province; National Engineering Laboratory for Biomass Chemical Utilization; Key and Open Laboratory on Forest Chemical Engineering, SFA, Nanjing 210042, China
Rutian Li
The Comprehensive Cancer Center, Drum-Tower Hospital of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
Jifu Wang
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; Key Laboratory of Biomass Energy and Material, Jiangsu Province; National Engineering Laboratory for Biomass Chemical Utilization; Key and Open Laboratory on Forest Chemical Engineering, SFA, Nanjing 210042, China
Meihong Liu
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; Key Laboratory of Biomass Energy and Material, Jiangsu Province; National Engineering Laboratory for Biomass Chemical Utilization; Key and Open Laboratory on Forest Chemical Engineering, SFA, Nanjing 210042, China
Chunpeng Wang
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry; Key Laboratory of Biomass Energy and Material, Jiangsu Province; National Engineering Laboratory for Biomass Chemical Utilization; Key and Open Laboratory on Forest Chemical Engineering, SFA, Nanjing 210042, China
Fuxiang Chu
Chinese Academy of Forestry, Beijing 100091, China

Corresponding Author: Chunpeng Wang

wangcpg@163.com

Nano-Micro Letters, Vol. 6 No. 3 (2014), Article Number: 200-208

Abstract

Hydrogel capsules show attractive prospects in drug delivery recently because of high drug loading and sustained release behavior. In this study we reported a simple and convenient route to fabricate poly (acrylic acid)-poly (N-isopropylacrylamide) (PAA-PNIPAm) hydrogel capsules by using hydroxypropylcellulose-poly (acrylic acid) (HPC-PAA) complexes as the templates. The capsules showed a high drug loading (∼280% to the weight of capsules) for Doxorubicin hydrochloride. The release of drug from the capsules was responsive to the temperature and pH of the surroundings, showing a low-rate but sustained release behavior favorable for low-toxic and long-term therapy. Together with the convenient preparation, high drug loading, dual responsivity as well as the sustained release feature, it is implied that this polymeric hydrogel capsule might be a promising candidate for new drug carriers.

Keywords

Hydrogel capsules Sustained release High drug loading Dual responsivity
Nan, Jingya, Ying Chen, Rutian Li, Jifu Wang, Meihong Liu, Chunpeng Wang, and Fuxiang Chu. 2014. “Polymeric Hydrogel Nanocapsules: A Thermo and PH Dual-Responsive Carrier for Sustained Drug Release”. Nano-Micro Letters 6 (3):200-208. https://doi.org/10.1007/BF03353784.
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