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Vol. 13 (2021)

Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes with Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection

https://doi.org/10.1007/s40820-020-00565-4
Yusi Peng
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
Chenglong Lin
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
Li Long
School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510641, People’s Republic of China
Tanemura Masaki
Department of Frontier Materials, Nagoya Institute of Technology, Nagoya 466‑8555, Japan
Mao Tang
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
Lili Yang
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
Jianjun Liu
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
Zhengren Huang
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China
Zhiyuan Li
School of Physics and Optoelectronics, South China University of Technology, Guangzhou 510641, People’s Republic of China
Xiaoying Luo
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, People’s Republic of China
John R. Lombardi
City College, CUNY, New York, NY, USA
Yong Yang
State Key Laboratory of High‑Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People’s Republic of China

Corresponding Author: Yong Yang

yangyong@mail.sic.ac.cn

Nano-Micro Letters, Vol. 13 (2021), Article Number: 52

Abstract

The outbreak of coronavirus disease 2019 has seriously threatened human health. Rapidly and sensitively detecting SARS-CoV-2 viruses can help control the spread of viruses. However, it is an arduous challenge to apply semiconductor-based substrates for virus SERS detection due to their poor sensitivity. Therefore, it is worthwhile to search novel semiconductor-based substrates with excellent SERS sensitivity. Herein we report, for the first time, Nb2C and Ta2C MXenes exhibit a remarkable SERS enhancement, which is synergistically enabled by the charge transfer resonance enhancement and electromagnetic enhancement. Their SERS sensitivity is optimized to 3.0 × 106 and 1.4 × 106 under the optimal resonance excitation wavelength of 532 nm. Additionally, remarkable SERS sensitivity endows Ta2C MXenes with capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein. Moreover, its detection limit is as low as 5 × 10−9 M, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus. This research not only provides helpful theoretical guidance for exploring other novel SERS-active semiconductor-based materials but also provides a potential candidate for the practical applications of SERS technology.


Highlights:


1 Nb2C and Ta2C MXenes exhibit remarkable SERS performance with the enhancement factors of 3.0 × 106 and 1.4 × 106, which is synergistically enabled by the PICT resonance enhancement and electromagnetic enhancement.
2 The excellent SERS sensitivity endows Ta2C MXene with the capability to sensitively detect and accurately identify the SARS-CoV-2 spike protein, which is beneficial to achieve real-time monitoring and early warning of novel coronavirus.

Keywords

Nb2C and Ta2C MXenes SERS sensitivity PICT resonance SARS-CoV-2 S protein
Peng, Yusi, Chenglong Lin, Li Long, Tanemura Masaki, Mao Tang, Lili Yang, Jianjun Liu, Zhengren Huang, Zhiyuan Li, Xiaoying Luo, John R. Lombardi, and Yong Yang. 2021. “Charge-Transfer Resonance and Electromagnetic Enhancement Synergistically Enabling MXenes With Excellent SERS Sensitivity for SARS-CoV-2 S Protein Detection”. Nano-Micro Letters 13 (January):52. https://doi.org/10.1007/s40820-020-00565-4.
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