Issue

Vol. 13 (2021)

In-Cell Nanoelectronics: Opening the Door to Intracellular Electrophysiology

https://doi.org/10.1007/s40820-021-00655-x
Dongxin Xu
State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou 510006, People’s Republic of China
Jingshan Mo
State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou 510006, People’s Republic of China
Xi Xie
State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou 510006, People’s Republic of China
Ning Hu
State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Sun Yat-Sen University, Guangzhou 510006, People’s Republic of China

Corresponding Author: Ning Hu

huning3@mail.sysu.edu.cn

Nano-Micro Letters, Vol. 13 (2021), Article Number: 127

Abstract

Establishing a reliable electrophysiological recording platform is crucial for cardiology and neuroscience research. Noninvasive and label-free planar multitransistors and multielectrode arrays are conducive to perform the large-scale cellular electrical activity recordings, but the signal attenuation limits these extracellular devices to record subthreshold activities. In recent decade, in-cell nanoelectronics have been rapidly developed to open the door to intracellular electrophysiology. With the unique three-dimensional nanotopography and advanced penetration strategies, high-throughput and high-fidelity action potential like signal recordings is expected to be realized. This review summarizes in-cell nanoelectronics from versatile nano-biointerfaces, penetration strategies, active/passive nanodevices, systematically analyses the applications in electrogenic cells and especially evaluates the influence of nanodevices on the high-quality intracellular electrophysiological signals. Further, the opportunities, challenges and broad prospects of in-cell nanoelectronics are prospected, expecting to promote the development of in-cell electrophysiological platforms to meet the demand of theoretical investigation and clinical application.


Highlights:


1 The factors affecting in-cell nanoelectronics for electrophysiology recording were discussed from versatile nano-biointerfaces, penetration strategies, active and passive nanodevices.
2 The applications of in-cell nanodevices in cardiomyocyte and neuron were further reviewed and evaluated.
3 The current challenges of nanodevices for intracellular electrophysiology and their potential applications in biomedical fields were discussed.

Keywords

In-cell nanoelectronics Nano-biointerfaces Intracellular electrophysiology Electrogenic cells
Xu, Dongxin, Jingshan Mo, Xi Xie, and Ning Hu. 2021. “In-Cell Nanoelectronics: Opening the Door to Intracellular Electrophysiology”. Nano-Micro Letters 13 (May):127. https://doi.org/10.1007/s40820-021-00655-x.
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