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Vol. 8 No. 1 (2016)

Peptide Functionalized Nanoplasmonic Sensor for Explosive Detection

https://doi.org/10.1007/s40820-015-0059-z
Diming Zhang
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China
Qian Zhang
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China
Yanli Lu
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China
Yao Yao
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China
Shuang Li
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China
Jing Jiang
Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA
Gang Logan Liu
Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign, Champaign, IL 61801, USA
Qingjun Liu
Biosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, People’s Republic of China

Corresponding Author: Qingjun Liu

qjliu@zju.edu.cn

Nano-Micro Letters, Vol. 8 No. 1 (2016), Article Number: 36-43

Abstract

In this study, a nanobiosensor for detecting explosives was developed, in which the peptide was synthesized with trinitrotoluene (TNT)-specific sequence and immobilized on nanodevice by Au–S covalent linkage, and the nanocup arrays were fabricated by nanoimprint and deposited with Au nanoparticles to generate localized surface plasmon resonance (LSPR). The device was used to monitor slight change from specific binding of 2,4,6-TNT to the peptide. With high refractive index sensing of ~104 nm/RIU, the nanocup device can detect the binding of TNT at concentration as low as 3.12 × 10−7 mg mL−1 by optical transmission spectrum modulated by LSPR. The nanosensor is also able to distinguish TNT from analogs of 2,4-dinitrotoluene and 3-nitrotoluene in the mixture with great selectivity. The peptide-based nanosensor provides novel approaches to design versatile biosensor assays by LSPR for chemical molecules.

Keywords

Nanocup arrays Peptide 2,4,6-trinitrotoluene (TNT) Localized surface plasmon resonance (LSPR) Nanosensor
Zhang, Diming, Qian Zhang, Yanli Lu, Yao Yao, Shuang Li, Jing Jiang, Gang Logan Liu, and Qingjun Liu. 2015. “Peptide Functionalized Nanoplasmonic Sensor for Explosive Detection”. Nano-Micro Letters 8 (1):36-43. https://doi.org/10.1007/s40820-015-0059-z.
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