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Vol. 10 No. 4 (2018)

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

https://doi.org/10.1007/s40820-018-0227-z
Peng Xue
Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, People’s Republic of China
Ruihao Yang
Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, People’s Republic of China
Lihong Sun
Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, People’s Republic of China
Qian Li
Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, People’s Republic of China
Lei Zhang
State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400716, People’s Republic of China
Zhigang Xu
Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, People’s Republic of China
Yuejun Kang
Faculty of Materials and Energy, Institute for Clean Energy and Advanced Materials, Southwest University, Chongqing 400715, People’s Republic of China

Corresponding Author: Yuejun Kang

yjkang@swu.edu.cn

Nano-Micro Letters, Vol. 10 No. 4 (2018), Article Number: 74

Abstract

Indocyanine green (ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation, which causes insufficient bioavailability at the tumor site. Herein, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe3O4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe3O4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.


Highlights:


1 An efficient photosensitizer, indocyanine green (ICG), was grafted on a nanocarrier via electrostatic adsorption, which effectively resolved poor circulation stability and tumoral bioavailability of free ICG molecules.
2 This composite nanoplatform comprised a magnetic core and a photothermal shell, which produced remarkable tumor suppression in vivo under combined photothermal and photodynamic therapy aided by magnetic guidance.

Keywords

Combination therapy Prussian blue nanoparticles Photothermal therapy Photodynamic therapy Indocyanine green
Xue, Peng, Ruihao Yang, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, and Yuejun Kang. 2018. “Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy”. Nano-Micro Letters 10 (4):74. https://doi.org/10.1007/s40820-018-0227-z.
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