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Vol. 12 (2020)

Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

https://doi.org/10.1007/s40820-020-00431-3
Xuanfang Zhou
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Zhouqi Meng
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Jialin She
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Yaojia Zhang
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Xuan Yi
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD‑X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Hailin Zhou
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD‑X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Jing Zhong
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD‑X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Ziliang Dong
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Xiao Han
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Muchao Chen
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Qin Fan
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Kai Yang
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection and School for Radiological and Interdisciplinary Sciences (RAD‑X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China
Chao Wang
Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon‑Based Functional Materials and Devices, Soochow University, Suzhou 215123, Jiangsu, People’s Republic of China

Corresponding Author: Chao Wang

cwang@suda.edu.cn

Nano-Micro Letters, Vol. 12 (2020), Article Number: 100

Abstract

Radiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor. However, NO cannot circulate in body with high concentration. Herein, an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy. Tert-Butyl nitrite, which is an efficient NO source, is coupled to Ag2S quantum dots (QDs). NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect. In addition, Ag is also a type of heavy metal that can benefit the RT therapy. We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model. Furthermore, immunosuppressive tumor microenvironment is improved by our NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. 100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms. Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.


Highlights:


1 Ag2S NO delivery platforms maximize radiotherapy effects remarkably to inhibit the tumor growth.
2 Immunosuppressive tumor microenvironment was improved by Ag2S NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy.

Keywords

NO delivery Radio sensitivity Multifunctional agent Radioimmunotherapy Drug delivery
Zhou, Xuanfang, Zhouqi Meng, Jialin She, Yaojia Zhang, Xuan Yi, Hailin Zhou, Jing Zhong, Ziliang Dong, Xiao Han, Muchao Chen, Qin Fan, Kai Yang, and Chao Wang. 2020. “Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy”. Nano-Micro Letters 12 (April):100. https://doi.org/10.1007/s40820-020-00431-3.
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